Noone Deirdre, Payne Jacob, Stott Josh, Aguirre Elisa, Patel-Palfreman Ms Mina, Stoner Charlotte, O Hanrachtaigh Eanna, Spector Aimee
Department of Clinical, Education and Health Psychology, University College London, UK.
North East London NHS Foundation Trust, UK.
Clin Gerontol. 2023 May-Jun;46(3):346-358. doi: 10.1080/07317115.2022.2094741. Epub 2022 Jul 12.
This preliminary study aimed to establish the feasibility of running an adapted Mindfulness Based Cognitive Therapy (MBCT) intervention for people with mild dementia and depression. It also aimed to conduct an exploratory analysis as to whether the MBCT intervention would lead to greater improvements in measures of depression, anxiety, quality of life and cognition, as compared to treatment as usual (TAU).
A single-blind, multisite, feasibility randomized controlled trial was used. People with dementia and depression were recruited from participating memory services. Twenty participants were randomized to either an adapted MBCT and TAU group (n = 10) or TAU (n = 10). Measures of depression, anxiety, quality of life (QOL), and cognition were assessed at baseline and follow-up.
The intervention was feasible in terms of high attendance and low levels of attrition. It was not judged feasible to recruit enough participants within the recruitment time-frame. The MBCT group did not show significant improvements in depression, anxiety, QOL, and cognition at follow-up, as compared to TAU.
There is currently inadequate evidence to recommend this adapted MBCT intervention for people with dementia for the treatment of depression within memory services. The MBCT intervention needs redevelopment and piloting before further testing in an RCT.
本初步研究旨在确定为轻度痴呆症和抑郁症患者开展适应性正念认知疗法（MBCT）干预的可行性。研究还旨在进行探索性分析，比较MBCT干预与常规治疗（TAU）相比，是否能在抑郁、焦虑、生活质量和认知测量方面带来更大改善。
采用单盲、多中心、可行性随机对照试验。从参与的记忆服务机构招募患有痴呆症和抑郁症的患者。20名参与者被随机分为适应性MBCT与TAU组（n = 10）或TAU组（n = 10）。在基线和随访时评估抑郁、焦虑、生活质量（QOL）和认知测量指标。
就高出勤率和低流失率而言，该干预是可行的。但在招募时间范围内招募到足够的参与者被认为不可行。与TAU相比，MBCT组在随访时抑郁、焦虑、QOL和认知方面未显示出显著改善。
目前没有足够的证据推荐这种适应性MBCT干预用于记忆服务机构中患有痴呆症的抑郁症患者的治疗。在进行随机对照试验进一步测试之前，MBCT干预需要重新开发和试点。
