Department of Medical Oncology-Gastroenterology and Urology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Neoplasma. 2022 Sep;69(5):1079-1091. doi: 10.4149/neo_2022_220225N209. Epub 2022 Jul 13.
Gastric cancer is the third most frequent cancer with high prevalence and mortality globally. Circular RNAs (circRNAs) play a key role in cancer regulation, including gastric cancer. Nevertheless, only a few circRNAs have been well elucidated in gastric cancer. Hence, we investigated the action of circ_0067514 on gastric cancer and clarified the underlying mechanism. Here, we found that circ_0067514 was decreased in gastric cancer patients and cancer cells. The circ_0067514 expression was correlated with gastric cancer overall survival, lymph node metastasis, tumor, node, metastasis (TNM) stage, and histological differentiation. Overexpression of circ_0067514 blocked proliferation, invasion, and glycolysis of gastric cancer cells. Besides, circ_0067514 regulated large tumor suppressor kinase 2 (LATS2) expression by absorbing microRNA (miR)-654-3p. Furthermore, circ_0067514 modulated gastric cancer aggressive behaviors and glycolysis via miR-654-3p/LATS2 axis. Moreover, circ_0067514 constrained tumor growth in vivo. Together, this study showed that circ_0067514 suppressed gastric cancer aggressive development and glycolysis via miR-654-3p/LATS2 axis, making circ_0067514 a valuable target for preventing gastric cancer progression.
胃癌是全球发病率和死亡率较高的第三大常见癌症。环状 RNA（circRNAs）在癌症调控中发挥着关键作用，包括胃癌。然而，只有少数 circRNAs 在胃癌中得到了很好的阐明。因此，我们研究了 circ_0067514 在胃癌中的作用，并阐明了其潜在机制。在这里，我们发现 circ_0067514 在胃癌患者和癌细胞中表达降低。circ_0067514 的表达与胃癌总生存期、淋巴结转移、肿瘤、淋巴结、转移（TNM）分期和组织学分化相关。circ_0067514 的过表达抑制了胃癌细胞的增殖、侵袭和糖酵解。此外，circ_0067514 通过吸收 microRNA（miR）-654-3p 来调节大肿瘤抑制激酶 2（LATS2）的表达。此外，circ_0067514 通过 miR-654-3p/LATS2 轴调节胃癌侵袭性行为和糖酵解。此外，circ_0067514 在体内抑制肿瘤生长。总之，这项研究表明，circ_0067514 通过 miR-654-3p/LATS2 轴抑制胃癌侵袭性发展和糖酵解，使 circ_0067514 成为预防胃癌进展的有价值的靶点。
