不同工业区肢端肥大症的高患病率：以色列北部海法和加利利西部地区的一项基于人群的研究。

High Prevalence of Acromegaly in Different Industrial Areas: A Population-based Study from Haifa and Western Galilee District in Northern Israel.

机构信息

Division of Endocrinology and Metabolism, Zvulun Medical Center, Kiryat Bialik, Israel.

Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

出版信息

Isr Med Assoc J. 2022 Jul;24(7):448-453.

PMID:35819213

Abstract

BACKGROUND

National registries for acromegaly and population-based data make an important contribution to disease understanding and management. Data concerning the epidemiology of acromegaly in Israel is scanty.

OBJECTIVES

To evaluate the epidemiology of acromegaly in different industrial areas in northern Israel.

METHODS

Data from adult patients diagnosed with acromegaly from 2000 to 2020, living in Haifa and the western Galilee District were collected using the electronic database and medical records from Clalit Health Services. The prevalence of acromegaly in three distinct areas and overall were reported. In addition, other epidemiological data including associated co-morbidities, pituitary tumor size, and treatment modalities were collected.

RESULTS

We identified 77 patients with a confirmed diagnosis of acromegaly. The overall prevalence was 155 cases/106 inhabitants without statistically significant differences between the three areas. The mean age at diagnosis was 50 ± 1.8 years and the male to female ratio was 1.1. Macroadenoma and microadenoma were identified in 44 (57%) and 25 (33%), respectively. The frequency rate of acromegaly-associated co-morbidities such as diabetes, hypertension, carpal tunnel syndrome, and osteoporosis was similar to previously reported studies. The mean body mass index (BMI) was 29 ± 5.6 kg/m2 .Obesity, with a BMI ≥ of 30 kg/m2, was found in 29 patients (38%). The majority of patients underwent transsphenoidal surgery 67 (87%). Normalized insulin-like growth factor 1 was reported in 64 (83%).

CONCLUSIONS

A high prevalence of acromegaly was found in northern Israel. The pituitary microadenoma frequency rate is the highest reported.

摘要

背景

肢端肥大症国家登记处和基于人群的数据为疾病的理解和管理做出了重要贡献。关于以色列肢端肥大症流行病学的数据很少。

目的

评估以色列北部不同工业区肢端肥大症的流行病学。

方法

使用电子数据库和克利夫兰医疗服务机构的医疗记录，收集了 2000 年至 2020 年期间居住在海法和加利利西部地区的确诊肢端肥大症的成年患者的数据。报告了三个不同地区和总体的肢端肥大症患病率。此外，还收集了其他流行病学数据，包括相关合并症、垂体肿瘤大小和治疗方式。

结果

我们共发现了 77 例确诊肢端肥大症患者。总体患病率为 155 例/106 名居民，三个地区之间没有统计学上的显著差异。诊断时的平均年龄为 50 ± 1.8 岁，男女比例为 1.1。44 例（57%）为大腺瘤，25 例（33%）为微腺瘤。肢端肥大症相关合并症（如糖尿病、高血压、腕管综合征和骨质疏松症）的发病率与之前的研究相似。平均体重指数（BMI）为 29 ± 5.6 kg/m2。29 例（38%）患者肥胖，BMI≥30 kg/m2。大多数患者接受了经蝶窦手术（67 例，87%）。64 例（83%）患者胰岛素样生长因子 1 正常化。