Dark D S, Pingleton S K, Kerby G R, Crabb J E, Gollub S B, Glatter T R, Dunn M I
Chest. 1987 Jun;91(6):833-6. doi: 10.1378/chest.91.6.833.
We observed breathing pattern abnormalities and arterial oxygen desaturation in patients with stable congestive heart failure during overnight polysomnography. To determine whether congestive heart failure was the reason for these abnormalities, we then studied six additional patients before and after treatment of heart failure. Breathing was more abnormal (153 +/- 87 episodes/night) during decompensation of heart failure and improved with medical therapy (72 +/- 100 episodes/night) (p less than 0.05). Abnormal breathing patterns resolved in three patients, improved in two, and were unchanged in one patient after therapy. Allographic cardiac transplantation in one patient whose sleep study remained unchanged after medical therapy was associated with resolution of breathing pattern abnormalities and severe desaturation during sleep. Therapy-related improvement in nocturnal respiratory events suggests congestive heart failure is a contributing factor for breathing abnormalities and arterial oxygen desaturation during sleep.
我们在夜间多导睡眠监测中观察到稳定型充血性心力衰竭患者存在呼吸模式异常和动脉血氧饱和度下降。为确定充血性心力衰竭是否为这些异常的原因，我们随后研究了另外6例心力衰竭治疗前后的患者。心力衰竭失代偿期呼吸异常更为明显（153±87次/夜），药物治疗后有所改善（72±100次/夜）（p<0.05）。治疗后，3例患者的异常呼吸模式消失，2例改善，1例无变化。1例药物治疗后睡眠研究结果未改变的患者接受同种异体心脏移植后，睡眠期间呼吸模式异常和严重血氧饱和度下降得到缓解。夜间呼吸事件与治疗相关的改善表明，充血性心力衰竭是睡眠期间呼吸异常和动脉血氧饱和度下降的一个促成因素。
