Internal Medicine, AP-HP, Saint-Louis Hospital, Paris Diderot University, Paris, France.
Rheumatology Department, Saint Gallen Kantonsspital, Saint Gallen, Switzerland.
Rheumatol Int. 2022 Oct;42(10):1721-1728. doi: 10.1007/s00296-022-05167-4. Epub 2022 Jul 12.
This prospective population-based study estimated the incidence of giant cell arteritis (GCA) in northeastern Paris. GCA cases diagnosed between 2015 and 2017 were obtained from local hospital and community-based physicians and the national health insurance system database. Criteria for inclusion were living in the study area at that time and fulfilling the 1990 American College of Rheumatology classification criteria and/or its expanded version. Cranial and large-vessel GCA cases were defined by the presence or absence of cranial signs and/or symptoms, respectively. Annual incidence was calculated by dividing the number of incident cases by the size of the study population ≥ 50 years old. Completeness of case ascertainment was assessed by a three-source capture-recapture analysis. Among the 62 included cases, 42 (68%) were women, mean (± SD) age 77.3 ± 9.1 years. The annual incidence of GCA in northeastern Paris and completeness of case ascertainment were estimated at 7.6 (95% CI 5.9-9.8) per 100,000 inhabitants ≥ 50 years old and 66% (95% CI 52-92%), respectively. Incidence increased with age, peaked at age 80-89 years, and was almost twice as high in women versus men. Large-vessel GCA cases, mean (± SD) age 68.6 ± 11.5 years, accounted for 8% of all GCA cases. In this study, GCA epidemiology was mainly driven by cases with cranial GCA signs or symptoms and incidence results were consistent with recent European and past French studies.
这项前瞻性基于人群的研究估计了巴黎东北部巨细胞动脉炎（GCA）的发病率。2015 年至 2017 年间，通过当地医院和社区医生以及国家健康保险系统数据库获得 GCA 病例。纳入标准为当时居住在研究区域内，并符合 1990 年美国风湿病学会分类标准和/或其扩展版。颅和大血管 GCA 病例分别通过存在或不存在颅部体征和/或症状来定义。通过将新发病例数除以≥50 岁的研究人群大小来计算年度发病率。通过三源捕获-再捕获分析评估病例确定的完整性。在纳入的 62 例病例中，42 例（68%）为女性，平均（±标准差）年龄为 77.3±9.1 岁。巴黎东北部 GCA 的年发病率和病例确定的完整性估计分别为每 100,000 名≥50 岁居民 7.6（95%置信区间 5.9-9.8）和 66%（95%置信区间 52-92%）。发病率随年龄增加而增加，在 80-89 岁年龄组达到峰值，女性是男性的两倍。大血管 GCA 病例，平均（±标准差）年龄 68.6±11.5 岁，占所有 GCA 病例的 8%。在这项研究中，GCA 流行病学主要由有颅 GCA 体征或症状的病例驱动，并且发病率结果与最近的欧洲和过去的法国研究一致。
