Guittet Lydia, de Boysson Hubert, Cerasuolo Damiano, Morello Rémy, Sultan Audrey, Deshayes Samuel, Aouba Achille
Caen Universisty Hospital, Caen, France.
University of Caen, Caen, France.
ACR Open Rheumatol. 2022 Sep;4(9):753-759. doi: 10.1002/acr2.11472. Epub 2022 Jun 13.
The incidence rate of giant cell arteritis (GCA) is poorly studied in France. Therefore, we conducted a national hospital database study to assess the overall and regional incidence rates of GCA in France, including overseas territories.
Through the national hospitalization database of all patients hospitalized in France, new incidental GCA was identified using International Classification of Diseases, 10th Revision medical codes (M31.5 = GCA; M31.6 = GCA and polymyalgia rheumatica [PMR]) during 2013-2019. The regional incidences were analyzed by graphical methods and Poisson regression.
A total of 16,540 new GCA with or without PMR diagnoses were identified in all French hospitals over 7 years. The female/male ratio was 1.8. The crude annual incidence rate of GCA with or without PMR was 9.64 (9.50-9.79) per 100,000 persons aged 50 years or older in continental France and 2.91 (2.35-3.47) in overseas areas. The GCA with or without PMR incidence rate regularly increased with age in both sexes but with a later peak in men (85 vs 80 years in women). The crude incidence rate was 11.43 (11.21-11.65) in women and 7.50 (7.31-7.70) in men. An east-western gradient was noted with an increasing standardized incident rate (SIR) from east to west (P < 10 ) using a departmental stratification of incident rates. Of note, all SIRs in continental regions were higher than those in overseas areas.
This French nationwide study provides new and dynamic insights regarding GCA with or without PMR incident rates at the country and regional levels. Important rate differences were observed between continental France and the overseas areas.
法国对巨细胞动脉炎（GCA）的发病率研究较少。因此，我们开展了一项全国性医院数据库研究，以评估法国（包括海外领地）GCA的总体发病率和地区发病率。
通过法国所有住院患者的全国住院数据库，利用国际疾病分类第10版医学编码（M31.5 = GCA；M31.6 = GCA和风湿性多肌痛[PMR]）在2013 - 2019年期间识别新发生的GCA。通过图形方法和泊松回归分析地区发病率。
在7年期间，法国所有医院共识别出16540例新诊断的伴有或不伴有PMR的GCA。女性/男性比例为1.8。在法国大陆，50岁及以上人群中伴有或不伴有PMR的GCA的粗年发病率为每10万人9.64（9.50 - 9.79），在海外地区为2.91（2.35 - 3.47）。伴有或不伴有PMR的GCA发病率在两性中均随年龄有规律地增加，但男性的峰值出现较晚（女性为80岁，男性为85岁）。粗发病率女性为11.43（11.21 - 11.65），男性为7.50（7.31 - 7.70）。采用按部门分层的发病率分析，发现从东到西标准化发病率（SIR）呈上升趋势（P < 10）。值得注意的是，大陆地区的所有SIR均高于海外地区。
这项法国全国性研究提供了关于伴有或不伴有PMR的GCA在国家和地区层面发病率的新的动态见解。在法国大陆和海外地区观察到了重要的发病率差异。
