颗粒酶在健康与疾病中的非细胞毒性作用
Noncytotoxic Roles of Granzymes in Health and Disease.
机构信息
International Collaboration on Repair Discoveries (ICORD), British Columbia Professional Firefighters' Wound Healing Laboratory, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Physiology (Bethesda). 2022 Nov 1;37(6):323-348. doi: 10.1152/physiol.00011.2022. Epub 2022 Jul 12.
Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Distinct substrate profiles and functions have since emerged for each granzyme while their dysregulated proteolytic activities have been linked to diverse pathologies.
颗粒酶是丝氨酸蛋白酶，以前被认为在淋巴细胞介导的靶细胞死亡中发挥独特且有些冗余的作用。然而，最近的研究挑战了这一模式。此后，每种颗粒酶的独特底物谱和功能逐渐显现出来，而它们失调的蛋白水解活性与多种病理有关。
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