Gaigne L, Piperoglou C, Banzet N, Ghellab L, Vély F, Schleinitz N, Ebbo M
Département de médecine interne, hôpital La Timone, CHU de Timone, Assistance publique-Hôpitaux de Marseille, Aix-Marseille université, Marseille, France.
Marseille immunopôle, hôpital de la Timone, Assistance publique-Hôpitaux de Marseille, Aix-Marseille université, Marseille, France.
Rev Med Interne. 2022 Sep;43(9):528-536. doi: 10.1016/j.revmed.2022.06.006. Epub 2022 Jul 9.
Anti-cytokine antibodies (ACA) are an emerging cause of acquired immunodeficiency, especially in previously healthy adults. The most frequently reported are anti-IFN-γ responsible for disseminated non-tuberculous mycobacteria infections, and anti-GM-CSF mainly in mycobacteria, cryptococcosis and nocardiosis infections. The presence of anti-IFN-α in severe COVID-19 infections has recently been described. The search for and detection of these ACAs in an unusual infection situation makes it possible to set up specific therapies in addition to the anti-infective treatment. ACAs are also frequent in various autoimmune pathologies where, in addition to being indicators of the breakdown of immune tolerance, they can modulate the activity of the disease according to their cytokine target. In this review of the literature, we will focus on the epidemiology and the clinical impact of these ACAs in healthy subjects and in infectious or dysimmune diseases.
抗细胞因子抗体（ACA）是获得性免疫缺陷的一个新兴原因，尤其是在既往健康的成年人中。最常报道的是导致播散性非结核分枝杆菌感染的抗IFN-γ，以及主要见于分枝杆菌、隐球菌病和诺卡菌病感染的抗GM-CSF。最近有报道称在重症COVID-19感染中存在抗IFN-α。在不寻常的感染情况下寻找和检测这些ACA，除抗感染治疗外还可开展特异性治疗。ACA在各种自身免疫性疾病中也很常见，它们除了是免疫耐受破坏的指标外，还可根据其细胞因子靶点调节疾病活动。在这篇文献综述中，我们将重点关注这些ACA在健康受试者以及感染性或免疫失调性疾病中的流行病学和临床影响。
