Zoology Department, Faculty of Science, Menoufia University, Shebin El Kom, 32511, Egypt.
Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Sci Rep. 2022 Jul 12;12(1):11839. doi: 10.1038/s41598-022-14770-1.
Cinnamon is a well-known natural spice and flavoring substance used worldwide. The objective of the present work is to explore the possible antitumor and immunomodulatory potencies of cinnamon essential oil (Cinn) on Ehrlich ascites carcinoma (EAC). A total of fifty female Swiss albino mice were sub-grouped into five groups (n = 10), namely, normal (a non-tumorized and non-treated) group; EAC-tumorized and non-treated group; Cinn (non-tumorized mice received Cinn, 50 mg/kg per body weight daily) group; a group of EAC-tumorized mice treated with Cinn and the final positive control group of EAC-tumorized mice received cisplatin. Eight compounds were identified from Cinn using UPLC-MS-Qtof and NMR analysis. Compared to EAC untreated group, Cinn successfully (P < 0.05) inhibited tumor growth by reducing tumor cell count (45%), viability (53%) and, proliferation accompanied by the inhibition of tumor growth rate. Moreover, a significant (P < 0.05) arrest in the cell cycle at G/G phase was noticed following Cinn treatments (~ 24.5%) compared to EAC group. Moreover, Cinn markedly evoked an antitumor immune response by elevating the percentage of splenic T helper (CD3CD4) and T cytotoxic (CD3CD8) cells. It is noteworthy that Cinn treatments significantly restored different hematological alterations as well as liver and kidney functions in EAC-tumorized mice. In conclusion, results suggest that Cinn has a good antitumor and immunostimulatory potencies against Ehrlich ascites carcinoma in vivo. The mechanism underlying its antitumor activity may be attributed to its immunostimulatory effects which increase its potential as a promising anticancer candidate.
肉桂是一种广受欢迎的天然香料和调味物质，在全球范围内使用。本研究旨在探索肉桂精油（Cinn）对艾氏腹水癌（EAC）的潜在抗肿瘤和免疫调节作用。将 50 只雌性瑞士白化病小鼠分为 5 组（n=10），分别为：正常组（非肿瘤未处理组）；EAC 肿瘤组且未处理组；Cinn 组（非肿瘤小鼠每日给予 Cinn，50mg/kg 体重）；EAC 肿瘤组给予 Cinn 治疗组；EAC 肿瘤组阳性对照组给予顺铂。使用 UPLC-MS-Qtof 和 NMR 分析从 Cinn 中鉴定出 8 种化合物。与未处理的 EAC 组相比，Cinn 通过减少肿瘤细胞计数（45%）、活力（53%）和增殖来成功（P<0.05）抑制肿瘤生长，同时抑制肿瘤生长速度。此外，与 EAC 组相比，Cinn 处理后细胞周期在 G0/G1 期显著（P<0.05）停滞，约为 24.5%。此外，Cinn 通过提高脾辅助性 T 细胞（CD3CD4）和 T 细胞毒性（CD3CD8）细胞的百分比，显著引发抗肿瘤免疫反应。值得注意的是，Cinn 治疗可显著恢复 EAC 肿瘤小鼠的不同血液学改变以及肝肾功能。综上所述，结果表明 Cinn 对艾氏腹水癌具有良好的抗肿瘤和免疫刺激作用。其抗肿瘤活性的机制可能归因于其免疫刺激作用，这增加了其作为一种有前途的抗癌候选物的潜力。
Zotero 插件