Radulski Débora Rasec, Stipp Maria Carolina, Galindo Claudia Martins, Acco Alexandra
Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.
Transl Breast Cancer Res. 2023 Jul 30;4:22. doi: 10.21037/tbcr-23-32. eCollection 2023.
Breast cancer is the most prevalent cancer worldwide, responsible for a large number of deaths, especially among women. Therapeutic options for breast cancer include surgery, radiotherapy, chemotherapy, hormone therapy, and immunotherapy, but further studies of the pathogenesis of this disease and new treatments are still needed. and cancer models are important research tools. Murine Ehrlich tumors are one of these models, especially for hormone-positive breast cancer. The present narrative review discusses characteristics of the Ehrlich tumor model, laboratory manipulations of Ehrlich cells (ECs), and applications in pharmacological, pathological, and translational studies.
This review was based on scientific articles, books, and theses on Ehrlich tumors. We searched the PubMed, SciELO, Google Scholar, Google, and Clarivate databases.
Hormone-positive ECs produce solid Ehrlich carcinoma (SEC) and ascitic Ehrlich carcinoma (AEC), with different features and applications. The presence of SEC or AEC induces systemic and immunological alterations that are similar to cancer in humans, what makes this model applicable to different studies in the cancer field.
Ehrlich tumors are a relevant tool for improving our understanding of the pathogenesis of breast cancer and investigating the tumor microenvironment, side effects of therapies, and new treatment options. Despite some limitations, such as the absence of an invasive phenotype to produce metastasis, both SEC and AEC are relevant in preclinical and translational studies of breast cancer.
乳腺癌是全球最常见的癌症，导致大量死亡，尤其是在女性中。乳腺癌的治疗选择包括手术、放疗、化疗、激素治疗和免疫治疗，但仍需要对该疾病的发病机制和新治疗方法进行进一步研究。癌症模型是重要的研究工具。小鼠艾氏瘤就是其中之一，尤其适用于激素阳性乳腺癌。本叙述性综述讨论了艾氏瘤模型的特点、艾氏细胞（ECs）的实验室操作以及在药理学、病理学和转化研究中的应用。
本综述基于关于艾氏瘤的科学文章、书籍和论文。我们检索了PubMed、SciELO、谷歌学术、谷歌和科睿唯安数据库。
激素阳性的ECs可产生实体艾氏癌（SEC）和腹水型艾氏癌（AEC），具有不同的特征和应用。SEC或AEC的存在会引发与人类癌症相似的全身和免疫改变，这使得该模型适用于癌症领域的不同研究。
艾氏瘤是增进我们对乳腺癌发病机制的理解以及研究肿瘤微环境、治疗副作用和新治疗选择的相关工具。尽管存在一些局限性，如缺乏产生转移的侵袭性表型，但SEC和AEC在乳腺癌的临床前和转化研究中都具有相关性。
