干扰素与衰老：将衰老与干扰素反应相联系
IFN-Aging: Coupling Aging With Interferon Response.
作者信息
Cao Wei
机构信息
Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
出版信息
Front Aging. 2022 May 2;3:870489. doi: 10.3389/fragi.2022.870489. eCollection 2022.
Abstract
Chronic inflammation affects many diseases and conditions, including aging. Interferons are a part of the immune defense against viral infections. Paradoxically, various aging tissues and organs from mammalian hosts perpetually accumulate changes brought by interferon pathway activation. Herein, we connote the mechanisms behind this phenomenon and discuss its implications in age-related pathology.
摘要
慢性炎症影响包括衰老在内的多种疾病和状况。干扰素是免疫防御病毒感染的一部分。矛盾的是，来自哺乳动物宿主的各种衰老组织和器官不断积累由干扰素途径激活带来的变化。在此，我们阐释这一现象背后的机制，并讨论其在与年龄相关的病理学中的意义。
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