[大鼠肝脏中N-亚硝基二乙胺代谢活化的额外途径]
[Additional pathway of the metabolic activation of N-nitrosodiethylamine in the rat liver].
作者信息
Khripach L V, Shuliakovskaia T S, Loknitskaia N N, Fonshteĭn L M
出版信息
Eksp Onkol. 1987;9(2):46-9.
PMID:3582239
Abstract
A cytosolic enzyme, aldehyde oxidase (AO), was shown to be involved in metabolic activation of carcinogenic diethylamine (DENA). DENA was reduced to corresponding hydrazines by AO in the presence of benzaldehyde. Products of DENA reduction by AO possessed mutagenic activity for Salmonella typhimurium TA 1950. Pretreatment of rats by antioxidant butylhydroxytoluene had no effect on this process of DNA bioactivation.
摘要
一种胞质酶，醛氧化酶（AO），已被证明参与致癌性二乙胺（DENA）的代谢活化。在苯甲醛存在的情况下，AO将DENA还原为相应的肼。AO还原DENA的产物对鼠伤寒沙门氏菌TA 1950具有诱变活性。用抗氧化剂丁基羟基甲苯对大鼠进行预处理对这一DNA生物活化过程没有影响。
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