Division of Pediatric Hematology Oncology, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, United States.
J Paediatr Child Health. 2022 Oct;58(10):1829-1835. doi: 10.1111/jpc.16118. Epub 2022 Jul 13.
Children with sickle cell disease (SCD) have historically weighed less than their healthy peers. More recently, a retrospective chart review from six institutions in New England reported nearly one-quarter of children and adolescents with SCD had raised body mass index (BMI). This study aimed to examine rates of children with SCD with raised BMI in Mississippi compared to state and national norms and assess the correlation between haemoglobin and BMI.
A retrospective chart review of paediatric patients with SCD at the University of Mississippi Medical Center (UMMC) was conducted using data from the most recent clinic visit. Mississippi and national weight status estimates for youth 10-17 years were obtained from the 2016-2017 National Survey of Children's Health.
For youth 10-17 years with SCD (n = 345), 21.4.% of children with SS/Sβ° and 36.1% with SC/Sβ had raised BMI compared to Mississippi and national rates, 39.2 and 31%, respectively. The prevalence of children with raised BMI with SC/Sβ did not differ from state and national rates, while children with SS/Sβ° were half as likely as their Mississippi peers to have raised BMI. Haemoglobin levels were different among children with SCD who had low BMI (8.80 g/dL), average BMI (9.2 g/dL) and raised BMI (10.5 g/dL) (P < 0.001).
Children with SCD evaluated at UMMC have similar rates of raised BMI compared to state and national norms. Children with raised BMI have higher mean haemoglobin levels compared to children with SCD with low or average BMI.
Historically, patients with SCD have been underweight and normal weight. Our paediatric and adolescent patients with SCD now have prevalence rates of raised BMI that approach state and national rates. Further work must be done to determine whether this reflects healthier children with SCD or raises concerns about life-style-related comorbidities.
患有镰状细胞病（SCD）的儿童体重历来低于健康同龄人。最近，新英格兰的六家机构进行了一项回顾性图表审查，报告称近四分之一的 SCD 儿童和青少年体重指数（BMI）升高。本研究旨在检查密西西比州 SCD 儿童 BMI 升高的比例与州和国家正常值相比，并评估血红蛋白与 BMI 之间的相关性。
使用密西西比大学医学中心（UMMC）最近一次就诊的患者数据，对 SCD 儿科患者进行回顾性图表审查。从 2016-2017 年全国儿童健康调查中获得了密西西比州和全国 10-17 岁青少年的体重状况估计值。
对于 10-17 岁的 SCD 青少年（n=345），SS/Sβ°儿童中 21.4%和 SC/Sβ°儿童中 36.1%的 BMI 升高，而密西西比州和全国的比例分别为 39.2%和 31%。SC/Sβ°儿童的 BMI 升高率与州和全国水平没有差异，而 SS/Sβ°°儿童的 BMI 升高率是密西西比州同龄人的一半。BMI 低（8.80g/dL）、平均 BMI（9.2g/dL）和 BMI 升高（10.5g/dL）的 SCD 儿童的血红蛋白水平不同（P<0.001）。
在 UMMC 接受评估的 SCD 儿童的 BMI 升高率与州和全国正常值相似。BMI 升高的儿童的平均血红蛋白水平高于 BMI 低或平均的 SCD 儿童。
历史上，SCD 患者体重过轻或体重正常。我们的儿科和青少年 SCD 患者现在的 BMI 升高率接近州和全国水平。还需要进一步努力确定这是否反映了 SCD 儿童的健康状况，还是对与生活方式相关的合并症表示担忧。
