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正常及病理状态下人体肾脏组织中的细胞质肌酸激酶

Cytoplasmic creatine kinase in normal and pathological human kidney tissue.

作者信息

González Buitrago J M, Corrales J J, Pastor I, Navajo J A, Montero J M, Miralles J M

出版信息

Eur Urol. 1987;13(1-2):100-2. doi: 10.1159/000472744.

DOI:10.1159/000472744
PMID:3582438
Abstract

Cytoplasmic creatine kinase (CK) activity was measured in 39 renal cortex samples from various kidney diseases. The highest CK values were observed in normal tissues (507 +/- 71). The mean values of CK enzymatic activity in the other groups decreased in the following order: chronic pyelonephritis (273 +/- 98), hydronephrosis (233 +/- 102), renal tuberculosis (133 +/- 34), pyonephrosis (96 +/- 46), and hypernephroma (45 +/- 33). The decrease in CK activity in kidney tissue paralleled tissue damage, and affects cellular functionality in relation with the processes that use adenosine 5'-triphosphate, such as the ionic pumps.

摘要

在39份来自各种肾脏疾病的肾皮质样本中测量了细胞质肌酸激酶(CK)活性。在正常组织中观察到最高的CK值(507±71)。其他组中CK酶活性的平均值按以下顺序降低:慢性肾盂肾炎(273±98)、肾积水(233±102)、肾结核(133±34)、肾积脓(96±46)和肾上腺皮质癌(45±33)。肾脏组织中CK活性的降低与组织损伤平行,并与使用三磷酸腺苷的过程(如离子泵)相关,影响细胞功能。

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