Mooy J, Böhm R, van Baak M, van Kemenade J, vd Vet A, Rahn K H
Eur J Clin Pharmacol. 1987;32(1):107-9. doi: 10.1007/BF00609969.
The influence of antituberculosis drugs on the plasma level of verapamil was studied after its oral and intravenous administration. Six patients who had been treated for at least 6 months with a combination of rifampicin, ethambutol and isoniazid received a single oral dose of 40 mg verapamil. As compared to untreated subjects, the antituberculosis drugs greatly reduced the bioavailability of the calcium antagonist. Studies in patients in whom treatment with ethambutol and isoniazid had been discontinued revealed that the effect was due to rifampicin. The drugs for tuberculosis had no influence on the plasma level of verapamil when it was given intravenously. The findings can be explained by the induction of verapamil metabolizing liver enzymes in patients treated with rifampicin.
研究了抗结核药物对口服和静脉注射维拉帕米后血浆水平的影响。6例接受利福平、乙胺丁醇和异烟肼联合治疗至少6个月的患者单次口服40mg维拉帕米。与未治疗的受试者相比，抗结核药物大大降低了钙拮抗剂的生物利用度。对已停用乙胺丁醇和异烟肼治疗的患者进行的研究表明，这种作用是由利福平引起的。静脉注射维拉帕米时，抗结核药物对其血浆水平没有影响。这些发现可以用利福平治疗患者中维拉帕米代谢性肝酶的诱导来解释。
