Whyte K F, Addis G J, Whitesmith R, Reid J L
Eur J Respir Dis. 1987 Apr;70(4):221-8.
An increase in circulating adrenaline and noradrenaline has been reported following acute dosing with theophyllines. This effect on catecholamines has been proposed as a possible mechanism of action of theophyllines. In a double-blind placebo controlled trial we have studied the effects of 5 days oral theophylline therapy on circulating catecholamines and adrenaline clearance. There were no significant changes in circulating catecholamines or adrenaline clearance following theophylline. We also examined the effects of theophylline on the hypokalaemic and haemodynamic actions of adrenaline. Theophylline increased the hypokalaemia, tachycardia and rise in systolic blood pressure which occurs in response to intravenous infusion of doses of L-adrenaline (0.02-0.06 microgram kg-1 min-1). Our results suggest that chronic theophylline therapy does not significantly increase circulating catecholamines. Increased circulating catecholamine concentrations are thus not an explanation for the chronic actions of theophylline. We have demonstrated significant, potentially hazardous metabolic and haemodynamic interactions between theophylline and adrenaline.
据报道，急性给予茶碱后，循环中的肾上腺素和去甲肾上腺素会增加。茶碱对儿茶酚胺的这种作用被认为是其可能的作用机制之一。在一项双盲安慰剂对照试验中，我们研究了5天口服茶碱治疗对循环儿茶酚胺和肾上腺素清除率的影响。茶碱治疗后，循环儿茶酚胺或肾上腺素清除率没有显著变化。我们还研究了茶碱对肾上腺素低钾血症和血流动力学作用的影响。茶碱会增加静脉输注L-肾上腺素（0.02-0.06微克/千克/分钟）剂量后出现的低钾血症、心动过速和收缩压升高。我们的结果表明，慢性茶碱治疗不会显著增加循环儿茶酚胺。因此，循环儿茶酚胺浓度升高并不能解释茶碱的慢性作用。我们已经证明了茶碱和肾上腺素之间存在显著的、潜在危险的代谢和血流动力学相互作用。
