Dubovik B V, Bogomazov S D
Farmakol Toksikol. 1987 Mar-Apr;50(2):116-21.
Based on the swimming test according to Kiplinger, in experiments on (CBA X C57BL)F1 mice there were elaborated criteria for animal performance evaluation in the process of repeated swimming of a standard distance thus measuring power, volume of work and rate of the fatigue development in relative units. From the study of effects of sydnocarb, bemethyl and phenazepam on various parameters of physical performance of mice a conclusion was made that the proposed method provides a more informative evaluation of the pharmacological effect on physical performance of animals as compared to the methods based on the record of time of performing the load.
基于基普林格的游泳测试,在(CBA×C57BL)F1小鼠实验中,制定了在标准距离重复游泳过程中评估动物表现的标准,从而以相对单位测量力量、工作量和疲劳发展速率。通过研究西地那非、贝美他嗪和吩那嗪对小鼠身体性能各项参数的影响,得出的结论是,与基于记录负荷执行时间的方法相比,所提出的方法能更全面地评估药物对动物身体性能的药理作用。