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[评估小鼠体力工作能力的多因素方法]

[Multifactorial method for assessing the physical work capacity of mice].

作者信息

Dubovik B V, Bogomazov S D

出版信息

Farmakol Toksikol. 1987 Mar-Apr;50(2):116-21.

PMID:3582626
Abstract

Based on the swimming test according to Kiplinger, in experiments on (CBA X C57BL)F1 mice there were elaborated criteria for animal performance evaluation in the process of repeated swimming of a standard distance thus measuring power, volume of work and rate of the fatigue development in relative units. From the study of effects of sydnocarb, bemethyl and phenazepam on various parameters of physical performance of mice a conclusion was made that the proposed method provides a more informative evaluation of the pharmacological effect on physical performance of animals as compared to the methods based on the record of time of performing the load.

摘要

基于基普林格的游泳测试,在(CBA×C57BL)F1小鼠实验中,制定了在标准距离重复游泳过程中评估动物表现的标准,从而以相对单位测量力量、工作量和疲劳发展速率。通过研究西地那非、贝美他嗪和吩那嗪对小鼠身体性能各项参数的影响,得出的结论是,与基于记录负荷执行时间的方法相比,所提出的方法能更全面地评估药物对动物身体性能的药理作用。

相似文献

1
[Multifactorial method for assessing the physical work capacity of mice].[评估小鼠体力工作能力的多因素方法]
Farmakol Toksikol. 1987 Mar-Apr;50(2):116-21.
2
[Effect of fenazepam on the ACTH content of the blood plasma in inbred mice under stress exposure].
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3
[Stimulation of prostaglandin E2 and F2a biosynthesis in the brains of mouse strain F1 (CBA X C57BL) by the tranquilizer phenazepam].[安定药非那西泮对F1(CBA×C57BL)品系小鼠大脑中前列腺素E2和F2α生物合成的刺激作用]
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[Comparative study of the effect of Ladasten, Sydnocarb and their combination on physical work ability of laboratory animals].[来达司特、西地卡波及其组合对实验动物体力工作能力影响的比较研究]
Eksp Klin Farmakol. 2006 May-Jun;69(3):68-70.
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Molecules. 2017 Jan 18;22(1):155. doi: 10.3390/molecules22010155.
2
The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.抗疲劳药物的药理学:改善精神和身体机能的实际应用。
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