School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, People's Republic of China.
Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, People's Republic of China.
Inflammopharmacology. 2022 Aug;30(4):1179-1187. doi: 10.1007/s10787-022-01026-7. Epub 2022 Jul 13.
NIMA-related kinase 7 (NEK7) is a serine/threonine kinase, which is the smallest one in mammalian NEK family. At present, many studies have reported that NEK7 has a physiological role in regulating the cell cycle and promoting the mitotic process of cells. In recent years, an increasing number of studies have proposed that NEK7 is involved in the activation of the NLRP3 inflammasome. Under normal conditions, NEK7 is in a low activity state, while under pathological conditions, NEK7 is abnormally expressed and therefore plays a key role in the progression of multiple tumors and chronic inflammatory diseases. This review will concentrate on the mechanism of NEK7 participates in the process of mitosis and regulates the activation of NLRP3 inflammasome, the aberrant expression of NEK7 in a variety of tumors and chronic inflammatory diseases, and some potential inhibitors, which may provide some new ideas for the treatment of diverse tumors and chronic inflammatory diseases associated with NEK7.
NIMA 相关激酶 7（NEK7）是一种丝氨酸/苏氨酸激酶，是哺乳动物 NEK 家族中最小的一种。目前，许多研究报道 NEK7 在调节细胞周期和促进细胞有丝分裂过程中具有生理作用。近年来，越来越多的研究提出 NEK7 参与 NLRP3 炎性小体的激活。在正常情况下，NEK7 处于低活性状态，而在病理条件下，NEK7 异常表达，因此在多种肿瘤和慢性炎症性疾病的进展中发挥关键作用。本综述将集中讨论 NEK7 参与有丝分裂过程和调节 NLRP3 炎性小体激活的机制，NEK7 在多种肿瘤和慢性炎症性疾病中的异常表达，以及一些潜在的抑制剂，这可能为治疗与 NEK7 相关的多种肿瘤和慢性炎症性疾病提供一些新的思路。
