Universidade Positivo - UP, School of Health Sciences, Dental School, Curitiba, PR, Brazil.
Universidade Federal do Paraná - UFPR, Dental School, Department of Stomatology, Curitiba, PR, Brazil.
Braz Oral Res. 2022 Jul 11;36:e089. doi: 10.1590/1807-3107bor-2022.vol36.0089. eCollection 2022.
This study aimed to evaluate the associations between oral health-related quality of life (OHRQoL) and patient-associated factors and polymorphisms in the estrogen receptor 1 (ESR1) and 2 (ESR2) genes in patients with dentofacial deformities (DFD). This cross-sectional study included 234 adult individuals. Data such as age, sex, and the type of facial profile (I, II, or III), were collected, and the short-form oral health impact profile 14 (OHIP-14) questionnaire was used to assess their OHRQoL. DNA was collected from oral mucosa cells, and the polymorphisms in ESR1 (rs2234693 and rs9340799) and ESR2 (rs1256049 and rs4986938) were evaluated using real-time polymerase chain reaction. The data were subjected to statistical analysis at a significance level of 5%. Individuals over 28 years of age exhibited worse OHRQoL (p = 0.003) than individuals aged less than or equal to 28 years. Women had worse OHRQoL than men (p < 0.001). Profile II individuals had worse OHRQoL in the social disability domain than profile III individuals (p = 0.030). Genetic analysis showed that rs9340799 was associated with OHRQoL in the functional limitation domain, and GG individuals exhibited worse OHRQoL than individuals carrying the AA/AG genotypes (p < 0.030). In the social handicap domain, individuals with GG genotype in rs9340799 exhibited worse OHRQoL than AG individuals (p < 0.043). Collectively, our results reveal that factors including age, sex, and type of facial profile, are associated with OHRQoL in patients with DFD. In addition, individuals with the GG genotype in rs9340799 (ESR1) may experience a negative impact on OHRQoL in the functional limitation and social handicap domains.
本研究旨在评估口腔健康相关生活质量（OHRQoL）与患者相关因素以及雌激素受体 1（ESR1）和 2（ESR2）基因多态性之间的关联，这些因素与牙颌面畸形（DFD）患者有关。这项横断面研究纳入了 234 名成年个体。收集了年龄、性别和面部轮廓类型（I、II 或 III）等数据，并使用简短口腔健康影响量表 14（OHIP-14）问卷评估了他们的 OHRQoL。从口腔黏膜细胞中提取 DNA，并使用实时聚合酶链反应评估 ESR1（rs2234693 和 rs9340799）和 ESR2（rs1256049 和 rs4986938）的多态性。数据在 5%的显著水平下进行了统计分析。28 岁以上的个体的 OHRQoL 比 28 岁及以下的个体差（p=0.003）。女性的 OHRQoL 比男性差（p<0.001）。II 型个体在社会障碍方面的 OHRQoL 比 III 型个体差（p=0.030）。遗传分析显示 rs9340799 与功能受限域的 OHRQoL 相关，GG 个体的 OHRQoL 比携带 AA/AG 基因型的个体差（p<0.030）。在社会障碍方面，rs9340799 的 GG 基因型个体的 OHRQoL 比 AG 个体差（p<0.043）。综上所述，我们的研究结果表明，年龄、性别和面部轮廓类型等因素与 DFD 患者的 OHRQoL 相关。此外，rs9340799（ESR1）中的 GG 基因型个体可能会对功能受限和社会障碍领域的 OHRQoL 产生负面影响。
