Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
J Obstet Gynaecol Res. 2022 Sep;48(9):2353-2362. doi: 10.1111/jog.15333. Epub 2022 Jul 13.
To test the hypothesis that a link existed between vitamin D levels in the first trimester and gestational diabetes mellitus (GDM).
The 25-hydroxyvitamin D levels were tested in the first trimester and pregnant outcomes were followed up in 1726 women.
Only 5.9% of pregnant women have sufficient 25(OH)D . More women with GDM are in the status of 25(OH)D insufficiency than women with normal glucose tolerance (NGT) (p < 0.05). Age (odds ratio [OR]: 1.047, 95% confidence interval [CI]: 1.014-1.081), pre-pregnancy body mass index (BMI) (OR: 1.132, 95%CI: 1.092-1.173) were risk factors of GDM while 25-(OH) D (OR: 0.979, 95%CI: 0.960-0.999) was a protective factor. After adjusted for maternal age and pre-pregnancy BMI, 25(OH)D insufficiency (<30 ng/mL) is an independent predictor of GDM (OR: 2.122, 95%CI: 1.084-4.155); 25(OH)D level correlated with fasting blood glucose in the first trimester negatively.
Vitamin D insufficiency in early pregnancy was significantly associated with an increased risk for GDM in Chinese women.
检验孕早期维生素 D 水平与妊娠期糖尿病（GDM）之间存在关联的假设。
在 1726 名女性中检测了孕早期的 25-羟维生素 D 水平，并随访了妊娠结局。
仅有 5.9%的孕妇 25(OH)D 充足。与糖耐量正常（NGT）的女性相比，GDM 女性中 25(OH)D 不足的比例更高（p<0.05）。年龄（比值比[OR]：1.047，95%置信区间[CI]：1.014-1.081）、孕前体重指数（BMI）（OR：1.132，95%CI：1.092-1.173）是 GDM 的危险因素，而 25-(OH)D（OR：0.979，95%CI：0.960-0.999）是保护因素。在校正了母亲年龄和孕前 BMI 后，25(OH)D 不足（<30ng/mL）是 GDM 的独立预测因素（OR：2.122，95%CI：1.084-4.155）；25(OH)D 水平与孕早期空腹血糖呈负相关。
孕早期维生素 D 不足与中国女性 GDM 风险增加显著相关。
