From the Department of Pathology (Otifi); from the Department of Surgery (Al-Shyarba), College of Medicine; from the Department of Clinical Laboratory Sciences (Abdul-Wahab, Al Fayi), Faculty of Applied Medical Sciences, King Khalid University, from the Department of Laboratory (Al Murea), Aseer Central Hospital, Abha, Kingdom of Saudi Arabia, and from the Specialized Unit of Mycoplasmas, Laboratory of Molecular Microbiology, Vaccinology, and Biotechnology Development (Yacoub), Institut Pasteur de Tunis, University of Tunis El-Manar, Tunis, Tunisia.
Saudi Med J. 2022 Jul;43(7):755-759. doi: 10.15537/smj.2022.43.7.20210758.
To determine the prevalence and characterize prostate cancer (PC) cases in Aseer, Saudi Arabia.
This study involved 883 patients who consulted physicians in Aseer Central Hospital, Abha, Saudi Arabia, for prostate issues between the years 2008-2018. All patients underwent digital rectal examination and measurement of their serum prostate-specific antigen levels. For patients who presented abnormal digital rectal examination findings and elevated prostate-specific antigen levels, prostate biopsies were recommended. Specimens were histopathologically examined to differentiate between malignant and benign tumors.
Among the 883 included patients, 132 (15%) underwent a prostate biopsy and were found to have a tumor. Histopathological examination confirmed malignancy (PC) in 77 (8.7%) patients. The absolute majority of the patients diagnosed with PC (96%) were aged >60 years and almost all of them (92%) were found to have a high prostate-specific antigen level of >4 ng/ml.
Prostate cancer appears to be a serious disease in Aseer, Saudi Arabia. Further studies aimed at determining the causes of this type of cancer and understanding its mechanisms are warranted.
确定沙特阿拉伯阿西尔地区前列腺癌（PC）的患病率并对其进行特征描述。
本研究纳入了 2008 年至 2018 年间在沙特阿拉伯阿卜哈的阿西尔中央医院因前列腺问题就诊的 883 例患者。所有患者均接受了直肠指检和血清前列腺特异性抗原水平检测。对于直肠指检结果异常和前列腺特异性抗原水平升高的患者，建议进行前列腺活检。对标本进行组织病理学检查，以区分恶性和良性肿瘤。
在 883 例纳入患者中，有 132 例（15%）接受了前列腺活检，发现有肿瘤。组织病理学检查证实 77 例（8.7%）患者患有恶性肿瘤（PC）。诊断为 PC 的绝大多数患者（96%）年龄>60 岁，几乎所有患者（92%）前列腺特异性抗原水平均>4ng/ml。
在沙特阿拉伯阿西尔地区，前列腺癌似乎是一种严重的疾病。有必要进一步研究确定此类癌症的病因，并了解其发病机制。
