神经保护护理包的实施与极早产儿长期神经发育结局的改善相关。
Neuroprotection care bundle implementation is associated with improved long-term neurodevelopmental outcomes in extremely premature infants.
机构信息
Department of Pediatrics, Section of Neonatology, University of Calgary, Calgary, AB, Canada.
Department of Diagnostic Imaging, Division of Neuroradiology, University of Calgary, Calgary, AB, Canada.
出版信息
J Perinatol. 2022 Oct;42(10):1380-1384. doi: 10.1038/s41372-022-01443-0. Epub 2022 Jul 13.
OBJECTIVE
To study the impact of an evidence-based neuroprotection care (NPC) bundle on long-term neurodevelopmental impairment (NDI) in infants born extremely premature.
STUDY DESIGN
An NPC bundle targeting predefined risk factors for acute brain injury in extremely preterm infants was implemented. We compared the incidence of composite outcome of death or severe neurodevelopmental impairment (sNDI) at 21 months adjusted age pre and post bundle implementation.
RESULTS
Adjusting for confounding factors, NPC bundle implementation associated with a significant reduction in death or sNDI (aOR, 0.34; 95% CI 0.17-0.68; P = 0.002), mortality (aOR, 0.31; 95% CI (0.12-0.79); P = 0.015), sNDI (aOR, 0.37; 95% CI: 0.12-0.94; P = 0.039), any motor, language, or cognitive composite score <70 (aOR, 0.48; 95% CI: 0.26-0.90; P = 0.021).
CONCLUSION
Implementation of NPC bundle targeting predefined risk factors is associated with a reduction in mortality or sNDI in extremely preterm infants.
目的
研究基于循证的神经保护护理（NPC）方案对极早产儿长期神经发育障碍（NDI）的影响。
研究设计
实施了针对极早产儿急性脑损伤的预设危险因素的 NPC 方案。我们比较了 NPC 方案实施前后调整至出生后 21 月龄的死亡或严重神经发育障碍（sNDI）复合结局的发生率。
结果
调整混杂因素后，NPC 方案的实施与死亡或 sNDI（aOR，0.34；95%CI，0.17-0.68；P=0.002）、死亡率（aOR，0.31；95%CI，0.12-0.79；P=0.015）、sNDI（aOR，0.37；95%CI：0.12-0.94；P=0.039）、任何运动、语言或认知复合评分 <70（aOR，0.48；95%CI：0.26-0.90；P=0.021）的降低显著相关。
结论
针对预设危险因素的 NPC 方案的实施与极早产儿的死亡率或 sNDI 的降低有关。
Zotero 插件