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真实世界中心脏团队在 TAVR 病例中推翻 STS 风险评分的临床因素和结果。

Clinical Factors and Outcomes When Real-World Heart Teams Overruled STS Risk Scores in TAVR Cases.

机构信息

Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.

Center for Cardiovascular Analytics, Research and Data Science, Providence Heart Institute, Providence St. Joseph Health, Portland, OR, USA.

出版信息

J Interv Cardiol. 2022 Jun 25;2022:9926423. doi: 10.1155/2022/9926423. eCollection 2022.

Abstract

OBJECTIVES

This study was conducted to determine why heart teams recommended transcatheter aortic valve replacement (TAVR) versus surgical AVR (SAVR) for patients at low predicted risk of mortality (PROM) and describe outcomes of these cases.

BACKGROUND

Historically, referral to TAVR was based predominately on the Society of Thoracic Surgeons (STS) risk model's PROM >3%. In selected cases, heart teams had latitude to overrule these scores. The clinical reasons and outcomes for these cases are unclear.

METHODS

Retrospective data were gathered for all TAVR and SAVR cases conducted by 9 hospitals between 2013 and 2017.

RESULTS

Cases included TAVR patients with STS PROM >3% ( = 2,711) and ≤3% ( = 415) and SAVR with STS PROM ≤3% ( = 1,438). Leading reasons for recommending TAVR in the PROM ≤3% group were frailty (57%), hostile chest (22%), severe lung disease (16%), and morbid obesity (13%), and 44% of cases had multiple reasons. Most postoperative and 30-day outcomes were similar between TAVR groups, but the STS PROM ≤3% group had a one-day shorter length of stay (2.5 ± 3.4 vs. 3.5 ± 4.7 days; ≤ 0.001) and higher one-year survival (91.6% vs. 86.0%, =0.002). In patients with STS PROM ≤3%, 30-day mortality was higher for TAVR versus SAVR (2.0% vs. 0.6%; < 0.001).

CONCLUSIONS

Heart teams recommended TAVR in patients with STS PROM ≤3% primarily due to frailty, hostile chest, severe lung disease, and/or morbid obesity. Similar postoperative outcomes between these patients and those with STS PROM >3% suggest that decisions to overrule STS PROM ≤3% were merited and may have reduced SAVR 30-day mortality rate.

摘要

目的

本研究旨在确定为何心脏团队建议低预测死亡率(PROM)患者进行经导管主动脉瓣置换术(TAVR)而非外科主动脉瓣置换术(SAVR),并描述这些病例的结局。

背景

传统上,TAVR 的转诊主要基于胸外科医师学会(STS)风险模型的 PROM>3%。在某些情况下,心脏团队可以放宽这些评分的限制。这些病例的临床原因和结局尚不清楚。

方法

回顾性收集了 2013 年至 2017 年间 9 家医院进行的所有 TAVR 和 SAVR 病例的数据。

结果

病例包括 STS PROM>3%( = 2711)和≤3%( = 415)的 TAVR 患者和 STS PROM≤3%( = 1438)的 SAVR 患者。推荐 STS PROM≤3%组进行 TAVR 的主要原因是虚弱(57%)、胸壁不适合(22%)、严重肺部疾病(16%)和病态肥胖(13%),44%的病例有多种原因。两组术后和 30 天结局相似,但 STS PROM≤3%组的住院时间短一天(2.5 ± 3.4 vs. 3.5 ± 4.7 天; ≤ 0.001),一年生存率更高(91.6% vs. 86.0%,=0.002)。STS PROM≤3%的患者中,TAVR 与 SAVR 的 30 天死亡率更高(2.0% vs. 0.6%; < 0.001)。

结论

心脏团队建议 STS PROM≤3%的患者进行 TAVR 主要是因为虚弱、胸壁不适合、严重肺部疾病和/或病态肥胖。这些患者与 STS PROM>3%的患者的术后结局相似,表明放宽 STS PROM≤3%的决定是合理的,可能降低了 SAVR 的 30 天死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a6f/9252751/deacb52891d2/JITC2022-9926423.001.jpg

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