不同性别成年高血压住院患者尿钠与尿钾排泄量和血压的相关性研究。

Study on the Correlation between Urinary Sodium and Potassium Excretion and Blood Pressure in Adult Hypertensive Inpatients of Different Sexes.

机构信息

Department of Cardiology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China.

Shanxi Medical University, Taiyuan 030001, China.

出版信息

Int J Clin Pract. 2022 Jun 30;2022:1854475. doi: 10.1155/2022/1854475. eCollection 2022.

DOI:10.1155/2022/1854475

PMID:35832799

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9262548/

Abstract

OBJECTIVE

This study aims to understand the difference in the influence of urinary sodium and potassium excretion on blood pressure in patients of different sexes with hypertension by analyzing the relationship between urinary sodium and potassium excretion and blood pressure.

METHODS

In this cross-sectional study, 606 hospitalized patients with essential hypertension were recruited from 16 hospitals in the Shanxi Province between June 2018 and December 2019. These patients were grouped by sex, with 368 males and 238 females. Basic information and relevant serum biochemical indexes of patients in the two groups were recorded. The 24-hour urinary sodium and potassium excretion were measured, and 24-hour ambulatory blood pressure monitoring was performed simultaneously. This was done to analyze and compare the relationship between urinary sodium and urinary potassium excretion and blood pressure in adult hospitalized patients of different sexes with hypertension.

RESULTS

The 24-hour urinary sodium excretion in male patients with hypertension was significantly higher than that in female patients ( < 0.001). There was no significant difference in 24-hour urinary potassium excretion between male patients with hypertension and female patients. Spearman correlation analysis showed that 24-hour urinary sodium excretion was positively correlated with 24-hour SBP and nSBP in male patients ( < 0.05), while 24-hour urinary potassium excretion was negatively correlated with 24-hour SBP and nSBP in male patients ( < 0.05). The 24-hour urinary sodium in female patients was significantly positively correlated with 24-hour SBP, 24-hour DBP, SBP, dDBP, nSBP, and nDBP ( < 0.01). The 24-hour urinary potassium was significantly negatively correlated with nSBP ( < 0.05). Multiple stepwise linear regression showed that 24-hour urinary sodium excretion was still significantly positively correlated with 24-hour SBP and nSBP in male patients with hypertension after adjusting for various confounding factors.

CONCLUSION

High urinary sodium and low urinary potassium excretion are closely related to elevated blood pressure in adult patients with hypertension, and there are sex differences.

摘要

目的

通过分析尿钠和尿钾排泄与血压的关系，了解不同性别高血压患者尿钠和尿钾排泄对血压影响的差异。

方法

本横断面研究纳入了 2018 年 6 月至 2019 年 12 月山西省 16 家医院收治的 606 例原发性高血压住院患者，按性别分组，其中男 368 例，女 238 例。记录两组患者的基本信息及相关血清生化指标，测量 24 小时尿钠和尿钾排泄量，并同步进行 24 小时动态血压监测，分析比较不同性别成年高血压住院患者尿钠和尿钾排泄与血压的关系。

结果

男性高血压患者 24 小时尿钠排泄量明显高于女性（<0.001），高血压男性患者 24 小时尿钾排泄量与女性患者比较差异无统计学意义。Spearman 相关分析显示，男性高血压患者 24 小时尿钠排泄量与 24 小时 SBP 和 nSBP 呈正相关（<0.05），而 24 小时尿钾排泄量与 24 小时 SBP 和 nSBP 呈负相关（<0.05）。女性患者 24 小时尿钠与 24 小时 SBP、24 小时 DBP、SBP、dDBP、nSBP 和 nDBP 呈明显正相关（<0.01），24 小时尿钾与 nSBP 呈明显负相关（<0.05）。多元逐步线性回归分析显示，调整多种混杂因素后，男性高血压患者 24 小时尿钠排泄量仍与 24 小时 SBP 和 nSBP 呈显著正相关。