Børresen A L, Leren T, Berg K, Solaas M H
Hum Hered. 1987;37(3):150-6. doi: 10.1159/000153693.
Haptoglobin (Hp) subtypes were analysed by two-dimensional high-resolution gel electrophoresis in 81 Norwegian individuals with moderate hypercholesterolemia and in 316 Norwegian control subjects. The frequencies of the genes Hp2SS and Hp2SF were higher in individuals with hypercholesterolemia than in controls but the differences did not reach statistical significance (p = 0.087). Within the control population, no effect of the different Hp subtypes was found on total serum cholesterol, triglycerides or high-density lipoprotein (HDL) cholesterol. However, in the controls a significantly higher frequency of Hp2-2 types was found among those with HDL cholesterol values in the upper quartile as compared to those with HDL cholesterol in the lower quartile. A similar phenomenon was not uncovered in analyses of total serum cholesterol or triglycerides. Our results are in agreement with others which indicate that genes belonging to the Hp polymorphism play a role in predicting an individual's total serum cholesterol level. However, our data indicate that the cholesterol effect is on the HDL rather than on the total cholesterol level.
采用二维高分辨率凝胶电泳法对81名患有中度高胆固醇血症的挪威人和316名挪威对照者的触珠蛋白（Hp）亚型进行了分析。高胆固醇血症患者中Hp2SS和Hp2SF基因的频率高于对照组，但差异未达到统计学显著性（p = 0.087）。在对照人群中，未发现不同Hp亚型对总血清胆固醇、甘油三酯或高密度脂蛋白（HDL）胆固醇有影响。然而，在对照组中，与HDL胆固醇处于下四分位数的人群相比，HDL胆固醇处于上四分位数的人群中Hp2-2型的频率显著更高。在总血清胆固醇或甘油三酯的分析中未发现类似现象。我们的结果与其他研究结果一致，表明属于Hp多态性的基因在预测个体总血清胆固醇水平方面发挥作用。然而，我们的数据表明，胆固醇效应作用于HDL而非总胆固醇水平。
