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老年人群颅底脑膜瘤切除术病例系列

Case Series of Skull Base Meningioma Resection in the Octogenarian Population.

作者信息

Kusyk Dorian M, Mao Gordon, Dabecco Rocco, Yu Alexander K

机构信息

Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States.

出版信息

J Neurol Surg B Skull Base. 2021 Feb 18;83(Suppl 2):e69-e74. doi: 10.1055/s-0040-1722711. eCollection 2022 Jun.

DOI:10.1055/s-0040-1722711
PMID:35832965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9272315/
Abstract

The geriatric population is the fastest growing segment of the American population, and octogenarians are increasingly seen by neurosurgeons for relatively common lesions such as meningiomas. Unfortunately, providers do not have clear data to guide decision-making regarding these lesions, particularly if they involve the skull base. Current research in outcomes among the elderly looks at a wide range of ages, often anyone older than 65. Previous studies in octogenarians report a wide-range of mortality rates and do not focus on skull base lesions. This paper strives to clarify the experiences and outcomes of octogenarians.  This retrospective series reviews skull base tumor surgeries performed at a single academic institution over the past 15 years in octogenarian patients. Primary endpoint was 30-day mortality; however, potential risk factors, perioperative morbidity, postdischarge disposition, and longer term follow-up were also captured. Multivariate logistic regression was performed to identify relevant perioperative and medical characteristics that increases the risk of adverse events.  Fourteen patients underwent craniotomies for skull base procedures with an average age of 84.5, with a 14% 30-day mortality rate. One patient required a tracheostomy on discharge and approximately half were able to either go home or rehabilitation after their procedure. On statistical analysis, there were no noted characteristics that predisposed any of the patients to a poorer outcome.  Octogenarian patients were able to tolerate surgery for skull base meningiomas resection. This outcome data may be used to inform surgical decision and guide conversation with patients and their families.

摘要

老年人群是美国人口中增长最快的部分,神经外科医生越来越多地诊治患有相对常见病变(如脑膜瘤)的八旬老人。不幸的是,医疗服务提供者没有明确的数据来指导针对这些病变的决策,特别是当病变累及颅底时。目前关于老年人治疗结果的研究涵盖了广泛的年龄范围,通常是任何65岁以上的人。先前针对八旬老人的研究报告了广泛的死亡率,且未聚焦于颅底病变。本文旨在阐明八旬老人的治疗经历和结果。

本回顾性系列研究回顾了过去15年在一家学术机构为八旬老人患者进行的颅底肿瘤手术。主要终点是30天死亡率;然而,还收集了潜在风险因素、围手术期发病率、出院后处置情况以及长期随访结果。进行多变量逻辑回归以确定增加不良事件风险的相关围手术期和医疗特征。

14名患者接受了颅底手术的开颅治疗,平均年龄为84.5岁,30天死亡率为14%。1名患者出院时需要气管切开术,约一半患者术后能够回家或接受康复治疗。经统计分析,未发现有任何特征使任何患者预后较差。

八旬老人患者能够耐受颅底脑膜瘤切除术。这些结果数据可用于为手术决策提供参考,并指导与患者及其家属的沟通。

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引用本文的文献

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Surgical outcomes in octogenarian meningioma patients: a multicenter retrospective analysis of frailty and radiological predictors : Frailty in octogenarians undergoing meningioma resection.八旬老人脑膜瘤患者的手术结局:一项关于衰弱和影像学预测因素的多中心回顾性分析:八旬老人行脑膜瘤切除术时的衰弱情况
J Neurooncol. 2025 Jul 22. doi: 10.1007/s11060-025-05174-y.

本文引用的文献

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