François Christopher J, Barton Gregory P, Corrado Philip A, Broman Aimee T, Chesler Naomi C, Eldridge Marlowe W, Wieben Oliver, Goss Kara N
Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (C.J.F.); Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex (G.P.B., K.N.G.); Departments of Medical Physics (G.P.B., P.A.C., O.W.), Radiology (O.W.), Biostatistics and Medical Informatics (A.T.B.), Pediatrics (M.W.E., K.N.G.), and Medicine (K.N.G.), School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wis; and Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center, University of California, Irvine, Calif (N.C.C.).
Radiol Cardiothorac Imaging. 2022 Jun 9;4(3):e210224. doi: 10.1148/ryct.210224. eCollection 2022 Jun.
To measure native T1 values, a marker of diffuse fibrosis, by using cardiac MRI (CMR) in young adults born prematurely.
This secondary analysis of a prospective cohort study included young adults born moderately to extremely preterm and age-matched, term-born participants. CMR was performed with a 3.0-T imager that included cine imaging for the quantification of left ventricular (LV) and right ventricular (RV) volumes and function and native saturation recovery T1 mapping for the assessment of diffuse myocardial fibrosis. Values between preterm and term were compared by using the Student test. Associations between T1 values and other variables were analyzed by using linear regression and multivariate regression.
Of the 50 young-adult participants, 32 were born preterm (mean age, 25.8 years ± 4.2 [SD]; 23 women) and 18 were born at term (mean age, 26.2 years ± 5.4; 10 women). Native T1 values were significantly higher in participants born preterm than in participants born at term (1477 msec ± 77 vs 1423 msec ± 71, respectively; unadjusted = .0019). Native T1 values appeared to be positively associated with indexed LV end-diastolic and end-systolic volumes (β = 2.1, standard error = 0.7 and β = 3.8, standard error = 1.2, respectively), the RV end-diastolic volume index (β = 1.3, standard error = 0.6), and the LV mass index (β = 2.5, standard error = 0.9). Higher T1 values may be associated with reduced cardiac systolic strain measures and diastolic strain measures. Five-minute Apgar scores were inversely associated with native T1 values.
Young adults born moderately to extremely preterm exhibited significantly higher native T1 values than age-matched, term-born young adults. MRI, Cardiac, Heart, Left Ventricle, CardiomyopathiesClinical trial registration no. NCT03245723Published under a CC BY 4.0 license
通过心脏磁共振成像（CMR）测量出生过早的年轻成年人的固有T1值，这是弥漫性纤维化的一个标志物。
这项前瞻性队列研究的二次分析纳入了中度至极早产出生的年轻成年人以及年龄匹配的足月出生参与者。使用3.0-T成像仪进行CMR检查，包括电影成像以定量左心室（LV）和右心室（RV）容积及功能，以及固有饱和恢复T1映射以评估弥漫性心肌纤维化。通过Student检验比较早产和足月参与者之间的值。使用线性回归和多变量回归分析T1值与其他变量之间的关联。
在50名年轻成年参与者中，32名早产（平均年龄25.8岁±4.2[标准差]；23名女性），18名足月出生（平均年龄26.2岁±5.4；10名女性）。早产参与者的固有T1值显著高于足月出生的参与者（分别为1477毫秒±77和1423毫秒±71；未校正P = 0.0019）。固有T1值似乎与左心室舒张末期和收缩末期容积指数呈正相关（β = 2.1，标准误 = 0.7和β = 3.8，标准误 = 1.2）、右心室舒张末期容积指数（β = 1.3，标准误 = 0.6）以及左心室质量指数（β = 2.5，标准误 = 0.9）。较高的T1值可能与心脏收缩应变测量值和舒张应变测量值降低有关。5分钟阿氏评分与固有T1值呈负相关。
中度至极早产出生的年轻成年人的固有T1值显著高于年龄匹配的足月出生的年轻成年人。磁共振成像、心脏、心脏、左心室、心肌病临床试验注册号：NCT03245723根据知识共享署名4.0许可发布
