Laheij A M G A, Raber-Durlacher J E, Hazenberg M D, Schoordijk M C E, Huysmans M C D N J M, de Visscher J G A M
Ned Tijdschr Tandheelkd. 2022 Jul;129(7-8):329-336. doi: 10.5177/ntvt.2022.07/08.22035.
Allogeneic stem cell transplantation can cause chronic graft versus host disease (cGVHD). A number of patients manifest cGVHD in and around the mouth. It can present itself as clinically as mucosal lesions and/or salivary gland dysfunction and/or sclerotic changes. Cheeks and tongue are most commonly affected, but the palate, gingiva and lips can also be impacted. Oral cGVHD is associated with mucosal sensitivity, pain, (severe) oral dryness, altered taste, restricted mouth opening and difficulty swallowing, all of which may contribute to a significant decrease of the patient's quality of life. Patients also run an increased risk of developing squamous cell carcinoma of the oral mucosa. The diagnosis of cGVHD is almost always based on the patient's medical history and clinical picture. Treatment of symptoms is based on the patient's problem(s). Dental professionals can provide patients with supportive preventive care aimed at reducing symptoms and preventing further deterioration of oral health.
异基因干细胞移植可导致慢性移植物抗宿主病（cGVHD）。许多患者会在口腔内及周围出现cGVHD。其临床表现可为黏膜病变和/或唾液腺功能障碍和/或硬化性改变。脸颊和舌头最常受累，但硬腭、牙龈和嘴唇也可能受到影响。口腔cGVHD会导致黏膜敏感、疼痛、（严重）口腔干燥、味觉改变、张口受限和吞咽困难，所有这些都可能导致患者生活质量显著下降。患者发生口腔黏膜鳞状细胞癌的风险也会增加。cGVHD的诊断几乎总是基于患者的病史和临床表现。症状的治疗基于患者的具体问题。牙科专业人员可以为患者提供支持性预防护理，旨在减轻症状并防止口腔健康进一步恶化。
