Kaldor J M, Day N E, Shiboski S
IARC Sci Publ. 1986(78):189-201.
In recent years, epidemiological methods have been used increasingly to study the carcinogenicity of drugs used in the chemotherapy of cancer. Such studies are useful to clinicians in identifying therapeutic agents with particular long-term risk to patients. They can also provide information on the dose- and time-related risks of cancer in one of the few human populations intentionally exposed to known levels of carcinogens. Aspects of epidemiological studies of second cancer risk are described, including sources of cases, study design, statistical methods, and possible biases. Results from a cohort study of second cancers following ovarian cancer, testicular cancer and Hodgkin's disease and from a case-control study of leukaemia following Hodgkin's disease are also given.
近年来，流行病学方法越来越多地用于研究癌症化疗药物的致癌性。此类研究对临床医生识别对患者有特定长期风险的治疗药物很有用。它们还可以在少数故意接触已知致癌物水平的人群中，提供与癌症相关的剂量和时间风险信息。本文描述了继发性癌症风险的流行病学研究方面，包括病例来源、研究设计、统计方法和可能的偏差。还给出了卵巢癌、睾丸癌和霍奇金病后继发性癌症队列研究以及霍奇金病后白血病病例对照研究的结果。
