Engel J, Schumacher W, Schönenberger H
IARC Sci Publ. 1986(78):295-307.
Studies on structure-activity relationships of organometallic anticancer drugs are reviewed. Three methods for the development of new structures are described. Drug targeting: platinum complexes with oestrophilic ligands were synthesized, and the endocrine and cytostatic effects are discussed. Quantitative structure-activity relationship determination is presented as a rational method for the design of active compounds. The molecular modelling technique is used for the analysis of molecular properties.
综述了有机金属抗癌药物构效关系的研究。描述了三种开发新结构的方法。药物靶向：合成了带有亲雌激素配体的铂配合物，并讨论了其内分泌和细胞抑制作用。定量构效关系的确定是设计活性化合物的一种合理方法。分子建模技术用于分析分子性质。
