Stanek K A, Coleman T G, Murphy W R
Hypertension. 1987 Jun;9(6):611-8. doi: 10.1161/01.hyp.9.6.611.
This study was designed to examine the total body hemodynamics of abdominal aortic coarctation hypertension. The study quantitates both regional and organ blood flow and resistance in conscious rats both above and below an experimentally produced coarctation. The experimental group consisted of 10 male Sprague-Dawley rats with a mean pressure gradient of 68 mm Hg across the coarctation. This experimental group was compared with a group of eight control rats with no pressure gradient. Flow measurements were made with radioactively labeled microspheres 4 weeks after aortic constriction. This aortic coarctation produced an increase in cardiac index (22%) and total peripheral resistance (19%). Blood flow through tissues proximal to the coarctation was not different from control; vascular resistance was increased (31%). Flow through the tissues distal to the coarctation was increased (16%); vascular resistance was decreased (-22%). The upper carcass, diaphragm, and brain were the tissues most representative of flow above the coarctation, and the lower carcass and large intestine were the tissues most representative of flow below the coarctation. Coarctation of the aorta produced cardiac hypertrophy and increased microsphere shunting to the lungs.
本研究旨在探讨腹主动脉缩窄性高血压的全身血流动力学。该研究对实验性制造的缩窄上方和下方清醒大鼠的局部和器官血流及阻力进行了定量分析。实验组由10只雄性Sprague-Dawley大鼠组成，缩窄部位的平均压力梯度为68毫米汞柱。该实验组与一组8只无压力梯度的对照大鼠进行了比较。在主动脉缩窄4周后，用放射性标记的微球进行血流测量。这种主动脉缩窄使心脏指数增加了22%，总外周阻力增加了19%。缩窄近端组织的血流与对照组无差异；血管阻力增加了31%。缩窄远端组织的血流增加了16%；血管阻力降低了22%。上半身、膈肌和大脑是缩窄上方血流最具代表性的组织，下半身和大肠是缩窄下方血流最具代表性的组织。主动脉缩窄导致心脏肥大，并增加了微球向肺部的分流。
