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芬替康唑与咪康唑乳膏的疗效及耐受性比较

Efficacy and tolerance of fenticonazole versus miconazole cream.

作者信息

Clerico R, Ribuffo A

出版信息

Int J Clin Pharmacol Res. 1987;7(1):77-81.

PMID:3583491
Abstract

On the basis of a randomized scheme, 40 patients affected by pityriasis versicolor, candidiasis or dermatophytosis were treated with fenticonazole 2% cream or with miconazole 2% cream. Clinical healing was obtained in 16 patients and there were four improvements in those treated with fenticonazole. In those treated with miconazole there were 14 clinically healed and five improvements. Only in two cases treated with miconazole and in one with fenticonazole, microscopic and cultural analysis had not become negative by the end of treatment. Both drugs were well tolerated. At the end of the study it was concluded that fenticonazole 2% cream is an effective antimycotic with an equal or even higher activity than miconazole.

摘要

根据随机方案,40例患有花斑癣、念珠菌病或皮肤癣菌病的患者接受了2%联苯苄唑乳膏或2%咪康唑乳膏治疗。16例患者实现临床治愈,接受联苯苄唑治疗的患者中有4例病情好转。接受咪康唑治疗的患者中有14例临床治愈,5例病情好转。仅2例接受咪康唑治疗的患者和1例接受联苯苄唑治疗的患者在治疗结束时镜检和培养分析仍未转阴。两种药物耐受性均良好。研究结束时得出结论,2%联苯苄唑乳膏是一种有效的抗真菌药,其活性与咪康唑相当甚至更高。

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