Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Division of Surgical Oncology, Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA.
Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Division of Abdominal Organ Transplantation, Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA.
Surg Oncol. 2022 Aug;43:101814. doi: 10.1016/j.suronc.2022.101814. Epub 2022 Jul 6.
Retroperitoneal and pelvis sarcomas are uncommon tumors for which complete surgical resection is the mainstay of treatment. However, achieving complete gross resection with microscopically negative margins is challenging, and local recurrence rates can be high. Patients often succumb to uncontrolled local disease. Radiation therapy offers a potential means for sterilizing microscopic residual disease, although its use continues to be controversial. Chemotherapy alone or in combination with radiation continues to be investigated as an adjunct to surgery, along with immunotherapy and targeted therapies. In this review, we discuss the current management of retroperitoneal and pelvis sarcomas, focusing on studies of surgery and radiation therapy to maximize local control.
腹膜后和骨盆肉瘤是罕见的肿瘤，完全手术切除是主要的治疗方法。然而，实现完整的大体切除和显微镜下阴性切缘是具有挑战性的，局部复发率可能很高。患者往往因无法控制的局部疾病而死亡。放射治疗为消灭显微镜下残留的疾病提供了一种潜在的手段，尽管其应用仍存在争议。化疗单独或联合放疗作为手术的辅助手段，以及免疫治疗和靶向治疗，仍在不断研究中。在这篇综述中，我们讨论了腹膜后和骨盆肉瘤的当前治疗方法，重点讨论了提高局部控制率的手术和放射治疗研究。
