West China School of Nursing, Sichuan University, Chengdu, China.
Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China; Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Mol Biochem Parasitol. 2022 Sep;251:111495. doi: 10.1016/j.molbiopara.2022.111495. Epub 2022 Jul 12.
Schistosoma is a genus of trematodes causing schistosomiasis, a major neglected tropical disease infecting more than 240 million people and with 700 million people at the risk of infection in the tropical and subtropical regions of the world, especially low-income countries. For the elimination of the disease, accurate diagnostic tools are needed. Besides allowing early treatment, early detection prevents environmental contamination and in turn ensures safe water sources in the endemic areas. Cell-free DNA (cfDNA) biomarker detection is a relatively new tool, used for the diagnosis of schistosomiasis in the early stages of infection from non-invasive clinical or experimental samples. cfDNA can be detected in Schistosoma infected host body fluids such as urine, serum, saliva and tissues, mainly in blood offering significant benefits for accurate diagnosis. In the current review, we described different characteristics of cfDNA, evidencing and supporting its potential uses in Schistosoma diagnosis and the improvement of treatment effectiveness.
曼氏血吸虫是一种引起血吸虫病的吸虫，血吸虫病是一种主要的被忽视热带病，感染了超过 2.4 亿人，在世界热带和亚热带地区，特别是低收入国家，有 7 亿人面临感染风险。为了消除这种疾病，需要准确的诊断工具。除了可以进行早期治疗外，早期检测还可以防止环境污染，从而确保流行地区的安全水源。无细胞游离 DNA (cfDNA) 生物标志物检测是一种相对较新的工具，用于在感染的早期阶段从非侵入性的临床或实验样本中诊断血吸虫病。cfDNA 可以在感染曼氏血吸虫的宿主体液中检测到，如尿液、血清、唾液和组织，主要在血液中，这为准确诊断提供了显著的优势。在本综述中，我们描述了 cfDNA 的不同特征，证明并支持了其在血吸虫病诊断和提高治疗效果方面的潜在用途。
