Washington National Primate Research Center, University of Washington, Seattle, Washington;, Email:
Washington National Primate Research Center, University of Washington, Seattle, Washington.
Comp Med. 2022 Aug 1;72(4):273-279. doi: 10.30802/AALAS-CM-21-000107. Epub 2022 Jul 14.
A 3-y-old male pigtailed macaque () presented for swelling of the left distal forearm and decreased use of the arm. The monkey had been raised at an indoor-outdoor facility in Arizona and transferred to an indoor facility in Washington 2 mo prior to presentation. A preliminary diagnosis of fungal osteomyelitis of the radius was made based on radiographs and titers. In addition to systemic antifungal treatment, surgery was performed to debride the bony lesion and implant polymethylmethacrylate beads impregnanted with the anti-fungal fluconazole. Histologic examination of the debrided material confirmed the diagnosis of fungal osteomyelitis. The surgical procedure resulted in clinical improvement, as evidenced by weight gain and decreased titers. The beads were removed in a second surgery, and the bony lesion completely resolved. With continued systemic fluconazole treatment, the monkey remained healthy with no further evidence of osteomyelitis. is an emerging pathogen that causes significant morbidity and mortality in both humans and animals. Bone infections can be resistant to systemic treatment, and the implantation of fluconazoleimpregnated beads may offer a successful treatment strategy for fungal osteomyelitis.
一只 3 岁雄性长尾猕猴（）因左前臂远端肿胀和手臂活动减少而就诊。这只猴子之前在亚利桑那州的室内外设施中饲养，在就诊前 2 个月被转移到华盛顿的室内设施中。根据 X 光片和滴度，初步诊断为桡骨真菌性骨髓炎。除了全身抗真菌治疗外，还进行了手术清创骨病变，并植入了含有抗真菌氟康唑的聚甲基丙烯酸甲酯珠。切除物的组织学检查证实了真菌性骨髓炎的诊断。手术导致了临床改善，表现为体重增加和滴度降低。在第二次手术中取出了珠子，骨病变完全消退。继续进行全身氟康唑治疗后，猴子仍然健康，没有进一步的骨髓炎证据。是一种新兴的病原体，可导致人类和动物严重的发病率和死亡率。骨骼感染可能对抗真菌药物治疗有抗性，植入氟康唑浸渍珠可能为真菌性骨髓炎提供一种成功的治疗策略。
