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生物膜的微观力学

Micromechanics of Biomembranes.

作者信息

Bhatia T

机构信息

Department of Physical Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, Knowledge City, Manauli, SAS Nagar, 140306, Punjab, India.

出版信息

J Membr Biol. 2022 Dec;255(6):637-649. doi: 10.1007/s00232-022-00254-w. Epub 2022 Jul 14.

Abstract

Micromechanics techniques are playing an increasing role in characterization of biomembranes. The mechanical properties of membranes play an important role for a whole range of cellular processes. Lipid-protein biomembranes display lateral heterogeneity, domain formation, and morphological changes at mesoscopic and nanoscopic length scales. An attempt is made to introduce how membrane's material properties can be measured. Both fluctuation analysis and micro-pipette aspiration experiments have been used to quantify the micromechanics of membranes. The relationship between the structure and function of biomembranes is a critical concern in modern biology. This overview calls for a deeper understanding of how the cell complexity might be related to the mechanical properties of the lipid-protein membrane. Mechanical properties can influence cellular response to processes like adhesion, transport, differentiation, proliferation and migration.

摘要

微力学技术在生物膜的表征中发挥着越来越重要的作用。膜的力学性质在一系列细胞过程中起着重要作用。脂质-蛋白质生物膜在介观和纳米尺度上表现出横向异质性、结构域形成和形态变化。本文试图介绍如何测量膜的材料性质。波动分析和微吸管抽吸实验都已被用于量化膜的微力学性质。生物膜的结构与功能之间的关系是现代生物学中的一个关键问题。本综述呼吁更深入地理解细胞复杂性与脂质-蛋白质膜的力学性质之间可能存在的联系。力学性质会影响细胞对诸如黏附、运输、分化、增殖和迁移等过程的反应。

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