Erickson-Lamy K A, Kaufman P L
Invest Ophthalmol Vis Sci. 1987 Jun;28(6):927-33.
Ciliary ganglionectomy and/or postganglionic ciliary neurectomy in the cynomolgus monkey was followed by supersensitivity to intramuscular (i.m.) pilocarpine and lack of response to topical eserine and to electrical stimulation of the Edinger-Westphal nucleus. Normal responsiveness to pilocarpine and eserine returned in most instances after about 6 months. An accommodative response to stimulus of the Edinger-Westphal nucleus was also present and, as in control eyes, could be blocked by hexamethonium. Collectively, these findings demonstrate that parasympathetic innervation to the ciliary muscle mediating accommodation traverses a typical peripheral autonomic synapse, almost certainly located predominantly in the ciliary ganglion; by 6 months after denervation, the ciliary muscles have reinnervated; and the parasympathetic pathway to the eye exhibits plasticity and capacity for regeneration.
在食蟹猴中进行睫状神经节切除术和/或节后睫状神经切除术之后，会出现对肌肉注射毛果芸香碱超敏，以及对局部应用依色林和对动眼神经核进行电刺激无反应的情况。在大多数情况下，大约6个月后对毛果芸香碱和依色林的正常反应性会恢复。对动眼神经核刺激的调节反应也存在，并且与对照眼一样，可被六甲铵阻断。总的来说，这些发现表明，介导调节的睫状肌副交感神经支配通过一个典型的外周自主神经突触，几乎可以肯定主要位于睫状神经节；去神经支配6个月后，睫状肌已重新获得神经支配；并且眼部的副交感神经通路表现出可塑性和再生能力。
