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在团队合作、目标、技术和严格控制方面的进展和未来方向——4T 研究:改善新诊断的儿童 1 型糖尿病的临床结局。

Advancements and future directions in the teamwork, targets, technology, and tight control-the 4T study: improving clinical outcomes in newly diagnosed pediatric type 1 diabetes.

机构信息

Division of Endocrinology, Department of Pediatrics, Stanford University, School of Medicine, Stanford.

Stanford Diabetes Research Center, Stanford, California, USA.

出版信息

Curr Opin Pediatr. 2022 Aug 1;34(4):423-429. doi: 10.1097/MOP.0000000000001140.

DOI:10.1097/MOP.0000000000001140
PMID:35836400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9298953/
Abstract

PURPOSE OF REVIEW

The benefits of intensive diabetes management have been established by the Diabetes Control and Complications Trial. However, challenges with optimizing glycemic management in youth with type 1 diabetes (T1D) remain across pediatric clinics in the United States. This article will review our Teamwork, Targets, Technology, and Tight Control (4T) study that implements emerging diabetes technology into clinical practice with a team approach to sustain tight glycemic control from the onset of T1D and beyond to optimize clinical outcomes.

RECENT FINDINGS

During the 4T Pilot study and study 1, our team-based approach to intensive target setting, education, and remote data review has led to significant improvements in hemoglobin A1c throughout the first year of T1D diagnosis in youth, as well as family and provider satisfaction.

SUMMARY

The next steps include refinement of the current 4T study 1, developing a business case, and broader implementation of the 4T study. In study 2, we are including a more pragmatic cadence of remote data review and disseminating exercise education and activity tracking to both English- and Spanish-speaking families. The overall goal is to create and implement a translatable program that can facilitate better outcomes for pediatric clinics across the USA.

摘要

目的综述

糖尿病控制和并发症试验已经证实了强化糖尿病管理的益处。然而,在美国的儿科诊所中,优化 1 型糖尿病(T1D)青少年的血糖管理仍然存在挑战。本文将回顾我们的团队合作、目标、技术和严格控制(4T)研究,该研究将新兴的糖尿病技术应用于临床实践,采用团队方法从 T1D 发病开始并持续进行严格的血糖控制,以优化临床结果。

最近的发现

在 4T 试点研究和研究 1 中,我们基于团队的强化目标设定、教育和远程数据审查方法,使青少年 T1D 诊断后的第一年的血红蛋白 A1c 显著改善,同时也提高了患者及其家属、医护人员的满意度。

总结

下一步包括完善当前的 4T 研究 1、制定商业案例以及更广泛地实施 4T 研究。在研究 2 中,我们增加了更具实际意义的远程数据审查频率,并向英语和西班牙语患者家庭提供运动教育和活动跟踪。总体目标是创建和实施一个可翻译的项目,以促进美国各地儿科诊所的更好结果。

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本文引用的文献

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NEJM Catal Innov Care Deliv. 2022 May;3(5). doi: 10.1056/CAT.21.0438. Epub 2022 Apr 20.
2
Algorithm-Enabled, Personalized Glucose Management for Type 1 Diabetes at the Population Scale: Prospective Evaluation in Clinical Practice.算法驱动的1型糖尿病群体规模个性化血糖管理:临床实践中的前瞻性评估
JMIR Diabetes. 2022 Jun 6;7(2):e27284. doi: 10.2196/27284.
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Strengths and Challenges of Closed-Loop Insulin Delivery During Exercise in People With Type 1 Diabetes: Potential Future Directions.
The adaptation of a single institution diabetes care platform into a nationally available turnkey solution.
将单一机构的糖尿病护理平台改编为全国可用的交钥匙解决方案。
NPJ Digit Med. 2024 Nov 6;7(1):311. doi: 10.1038/s41746-024-01319-x.
4
'We're taught green is good': Perspectives on time in range and time in tight range from youth with type 1 diabetes, and parents of youth with type 1 diabetes.我们被教导绿色是好的:从青少年 1 型糖尿病患者及其家长的角度来看,血糖控制在目标范围内和血糖控制在严格范围内的时间。
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Role and Perspective of Certified Diabetes Care and Education Specialists in the Development of the 4T Program.认证糖尿病护理与教育专家在4T项目开发中的角色与视角
Diabetes Spectr. 2024 Spring;37(2):153-159. doi: 10.2337/ds23-0010. Epub 2024 Jan 19.
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Equitable implementation of a precision digital health program for glucose management in individuals with newly diagnosed type 1 diabetes.新诊断为 1 型糖尿病患者的血糖管理精准数字健康计划的公平实施。
Nat Med. 2024 Jul;30(7):2067-2075. doi: 10.1038/s41591-024-02975-y. Epub 2024 May 3.
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