Hunzeker Zachary E, Bhakta Pooja, Gudipally Sindusha R, Kavuri Sri Bharathi, Venkatesan Rohit, Nwanze Chukwuyejulumafor
Medicine, University of Texas Medical Branch, Galveston, USA.
Internal Medicine, University of Texas Medical Branch, Galveston, USA.
Cureus. 2022 Jun 10;14(6):e25820. doi: 10.7759/cureus.25820. eCollection 2022 Jun.
Gastric cancer, a leading cause of cancer-related death in the world, may occur with an additional synchronous malignancy in rare cases. Of these rare cases many are colorectal cancer. Microsatellite instability is a phenomenon that may contribute to the pathogenesis of both cancers, as are field cancerization and genetic susceptibility, although none of these explain many concurrent cases. In this case, we described a patient with locally advanced microsatellite instability-high gastric cancer and synchronous microsatellite stable rectal cancer, who received a combination chemo-immunotherapy regimen and achieved complete response. This report reflects on current knowledge surrounding synchronous primary malignancies and achieving complete response.
胃癌是全球癌症相关死亡的主要原因之一，在罕见情况下可能会同时发生另一种同步性恶性肿瘤。在这些罕见病例中，许多是结直肠癌。微卫星不稳定性是一种可能导致这两种癌症发病机制的现象，场癌化和遗传易感性也是如此，尽管这些都无法解释许多同时发生的病例。在此病例中，我们描述了一名患有局部晚期微卫星高度不稳定型胃癌和同步性微卫星稳定型直肠癌的患者，该患者接受了联合化疗免疫治疗方案并实现了完全缓解。本报告反映了围绕同步性原发性恶性肿瘤及实现完全缓解的现有知识。
