Li Gang, Tang Liang-Jie, Zhu Pei-Wu, Huang Ou-Yang, Rios Rafael S, Zheng Kenneth I, Chen Sui-Dan, Ma Hong-Lei, Targher Giovanni, Byrne Christopher D, Pan Xiao-Yan, Zheng Ming-Hua
NAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
J Clin Transl Hepatol. 2022 Jun 28;10(3):439-448. doi: 10.14218/JCTH.2021.00286. Epub 2021 Oct 22.
Intra-abdominal visceral fat accumulation and patatin-like phospholipase domain containing 3 () rs738409 G/C gene polymorphism confer a greater susceptibility to nonalcoholic fatty liver disease (NAFLD). We examined whether the relationship between visceral fat accumulation and liver disease severity may be influenced by rs738409 polymorphism.
The variant of rs738409 was genotyped within 523 Han individuals with biopsy-confirmed NAFLD. Visceral fat area (VFA) was measured by bioelectrical impedance. Significant liver fibrosis (SF), defined as stage F ≥2 on histology, was the outcome measure of interest.
The distribution of genotypes was CC: 27.5%, CG: 48.2%, and GG: 24.3%. Higher VFA was associated with greater risk of having SF (adjusted-odds ratio [OR]: 1.03; 95% confidence interval [CI]: 1.02-1.04, <0.05), independent of potential confounders. Among subjects with the same VFA level, the risk of SF was greater among carriers of the rs738409 G genotype than among those who did not. Stratified analysis showed that rs738409 significantly influenced the association between VFA and SF. VFA remained significantly associated with SF only among the rs738409 G-allele carriers (adjusted-OR: 1.05; 95% CI: 1.03-1.08 for the GG group; and adjusted-OR:1.03; 95% CI: 1.01-1.04 for the GC group). There was a significant interaction between VFA and rs738409 genotype (P =0.004).
rs738409 G allele has a moderate effect on the association between VFA and risk of SF in adult individuals with biopsy-proven NAFLD. Existence of the rs738409 G allele and VFA interact to increase risk of SF.
腹内内脏脂肪堆积以及含patatin样磷脂酶结构域3（）rs738409 G/C基因多态性会增加非酒精性脂肪性肝病（NAFLD）的易感性。我们研究了内脏脂肪堆积与肝脏疾病严重程度之间的关系是否会受到rs738409多态性的影响。
对523名经活检确诊为NAFLD的汉族个体进行rs738409变异的基因分型。通过生物电阻抗测量内脏脂肪面积（VFA）。显著肝纤维化（SF）定义为组织学分期F≥2，是感兴趣的结局指标。
基因型分布为CC：27.5%，CG：48.2%，GG：24.3%。较高的VFA与发生SF的风险增加相关（校正比值比[OR]：1.03；95%置信区间[CI]：1.02 - 1.04，<0.05），独立于潜在混杂因素。在相同VFA水平的受试者中，rs738409 G基因型携带者发生SF的风险高于非携带者。分层分析表明，rs738409显著影响VFA与SF之间的关联。仅在rs738409 G等位基因携带者中，VFA与SF仍显著相关（GG组校正OR：1.05；95% CI：1.03 - 1.08；GC组校正OR：1.03；95% CI：1.01 - 1.04）。VFA与rs738409基因型之间存在显著交互作用（P = 0.004）。
在经活检证实为NAFLD的成年个体中，rs738409 G等位基因对VFA与SF风险之间的关联有中度影响。rs738409 G等位基因的存在与VFA相互作用会增加SF风险。
