Yang Litao, Zhang Bo
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University College of Biochemical Engineering, Beijing, China.
Evid Based Complement Alternat Med. 2022 Jul 5;2022:1745244. doi: 10.1155/2022/1745244. eCollection 2022.
Kütz. polysaccharide (NSKP) is one of the main components of Kütz. and is often used as health food. We investigated whether NSKP interferes with the progression of liver fibrosis. Male mice were randomly divided into 4 groups: control (C), high-fat diet (M), high-fat diet + 0.4 g/kg NSKP (L), and high-fat diet + 0.8 g/kg NSKP (H). C was fed standard diet, M was fed high-fat diet, and L and H were fed high-fat diet in addition to gavage of 0.4 g/kg or 0.8 g/kg NSKP, respectively, for 22 weeks. At the end of the experiment, the serum and liver oxidative stress, fat accumulation, and fibrosis indexes were detected. The histopathology of liver was also observed. The results showed that the rice of NSKP, compared with M, improved blood lipid level, liver total cholesterol (TC), triglyceride (TG), and liver antioxidant capacity and effectively interfered with liver fibrosis related indicators. So it is interesting to note that NSKP appeared to be effective in liver injury; further experiments are necessary to clarify the exact mechanisms involved.
昆布多糖（NSKP）是昆布的主要成分之一，常被用作保健食品。我们研究了NSKP是否会干扰肝纤维化的进程。将雄性小鼠随机分为4组：对照组（C）、高脂饮食组（M）、高脂饮食+0.4 g/kg NSKP组（L）和高脂饮食+0.8 g/kg NSKP组（H）。C组给予标准饮食，M组给予高脂饮食，L组和H组除分别灌胃0.4 g/kg或0.8 g/kg NSKP外，也给予高脂饮食，持续22周。实验结束时，检测血清和肝脏的氧化应激、脂肪堆积及纤维化指标。同时观察肝脏的组织病理学变化。结果显示，与M组相比，NSKP改善了血脂水平、肝脏总胆固醇（TC）、甘油三酯（TG）以及肝脏抗氧化能力，并有效干扰了肝纤维化相关指标。因此，值得注意的是NSKP似乎对肝损伤有效；有必要进行进一步实验以阐明其中的确切机制。
