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抗胸腺细胞球蛋白治疗后严重再生障碍性贫血完全自体骨髓重建。1例报告并文献复习。

Severe aplastic anaemia with complete autologous marrow reconstitution following treatment with antithymocyte globulin. Report of a case and review of the literature.

作者信息

Pedersen-Bjergaard J, Ernst P, Nissen N I

出版信息

Scand J Haematol. 1978 Jul;21(1):14-8. doi: 10.1111/j.1600-0609.1978.tb02489.x.

DOI:10.1111/j.1600-0609.1978.tb02489.x
PMID:358370
Abstract

In a patient with end-stage acquired aplastic anaemia, unsuccessful treatment with splenectomy, prednisone, pyridoxine and anabolic steroid was followed by administration of antithymocyte globulin (ATG). This therapy soon led to a gradual improvement and after 12 months, complete remission was obtained. The possible mechanism of action of ATG and the general principles of treatment are discussed.

摘要

在一名晚期获得性再生障碍性贫血患者中,脾切除术、泼尼松、吡哆醇和同化类固醇治疗均未成功,随后给予抗胸腺细胞球蛋白(ATG)治疗。该治疗很快使病情逐渐改善,12个月后获得完全缓解。本文讨论了ATG可能的作用机制及治疗的一般原则。

相似文献

1
Severe aplastic anaemia with complete autologous marrow reconstitution following treatment with antithymocyte globulin. Report of a case and review of the literature.抗胸腺细胞球蛋白治疗后严重再生障碍性贫血完全自体骨髓重建。1例报告并文献复习。
Scand J Haematol. 1978 Jul;21(1):14-8. doi: 10.1111/j.1600-0609.1978.tb02489.x.
2
Antithymocyte globulin treatment of severe aplastic anaemia.抗胸腺细胞球蛋白治疗重型再生障碍性贫血。
Br J Haematol. 1983 Sep;55(1):17-25. doi: 10.1111/j.1365-2141.1983.tb01220.x.
3
Comparison between bone marrow transplantation and antithymocyte globulin in treatment of young patients with severe aplastic anemia.骨髓移植与抗胸腺细胞球蛋白治疗年轻重型再生障碍性贫血患者的比较。
J Pediatr. 1984 Dec;105(6):920-5. doi: 10.1016/s0022-3476(84)80078-5.
4
[Treatment of severe aplastic anemia with bone marrow transplants or with antithymocyte globulin. Evaluation of 27 patients].
Rev Clin Esp. 1989 Feb;184(3):121-4.
5
Treatment of adults with severe aplastic anemia: primary therapy with antithymocyte globulin (ATG) and rescue of ATG failures with bone marrow transplantation.成人重型再生障碍性贫血的治疗:抗胸腺细胞球蛋白(ATG)作为初始治疗及骨髓移植挽救ATG治疗失败的患者
Am J Med. 1992 Jun;92(6):596-602. doi: 10.1016/0002-9343(92)90776-8.
6
Clonal remission in aplastic anemia after treatment with antithymocyte globulin.抗胸腺细胞球蛋白治疗后再生障碍性贫血的克隆缓解
Am J Hematol. 1992 Jul;40(3):229-31. doi: 10.1002/ajh.2830400314.
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[Treatment of aplastic anemia with antithymocyte globulin].
Harefuah. 1990 Jan 15;118(2):72-4.
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Treatment of severe aplastic anaemia with anti-thymocyte globulin.用抗胸腺细胞球蛋白治疗重型再生障碍性贫血。
Acta Haematol. 1985;74(3):144-7. doi: 10.1159/000206190.
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Re-treatment of aplastic anemia with antithymocyte globulin or antilymphocyte serum.用抗胸腺细胞球蛋白或抗淋巴细胞血清对再生障碍性贫血进行再治疗。
Am J Med. 1988 Apr;84(4):678-82. doi: 10.1016/0002-9343(88)90104-0.
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Unrelated donor marrow transplantation for severe acquired aplastic anemia using cyclophosphamide, antithymocyte globulin, and total body irradiation.使用环磷酰胺、抗胸腺细胞球蛋白和全身照射进行无关供体骨髓移植治疗严重获得性再生障碍性贫血。
Blood. 1995 Jan 1;85(1):291-2.

引用本文的文献

1
Proceedings of the Annual Meeting of the European Foundation for Bone Marrow Transplantation, Sils Maria (Engadine), Switzerland, April 13-16, 1980.欧洲骨髓移植基金会年度会议论文集,瑞士锡尔斯玛利亚(恩加丁),1980年4月13日至16日。
Blut. 1980 Sep;41(3):151-245. doi: 10.1007/BF02464145.