Gnesotto Laura, Mioso Guido, Alaibac Mauro
Dermatology Unit, Department of Medicine, University of Padova, I-35128 Padova, Italy.
Exp Ther Med. 2022 Jun 24;24(2):536. doi: 10.3892/etm.2022.11463. eCollection 2022 Aug.
Adsorptive granulocyte and monocyte apheresis (GMA) is an extracorporeal treatment that selectively removes activated myeloid lineage leukocytes from peripheral blood. This technique consists of a column with cellulose acetate beads as absorptive leukocytapheresis carriers, and was initially used to treat ulcerative colitis. A literature search was conducted to extract recently published studies about the clinical efficacy of GMA in patients with different skin disorders, reporting information on demographics, clinical symptoms, treatment and clinical course. Dermatological diseases, in which GMA has been performed, include generalized pustular psoriasis, pyoderma gangrenosum, palmoplantar pustular psoriasis, Behcet's disease, Sweet's syndrome, adult-onset Still's disease, impetigo herpetiformis, reactive arthritis, acne and hidradenitis suppurativa syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus. In most patients, GMA was started after the failure of conventional therapeutic options and it was helpful in the majority of cases. Based on the information summarized, GMA could be considered a valid non-pharmacological treatment option for patients with several dermatological conditions, which are difficult to treat with other pharmacological preparations.
吸附性粒细胞和单核细胞单采术（GMA）是一种体外治疗方法，可从外周血中选择性去除活化的髓系白细胞。该技术由一个装有醋酸纤维素珠作为吸附性白细胞单采载体的柱组成，最初用于治疗溃疡性结肠炎。进行了文献检索，以提取最近发表的关于GMA对不同皮肤疾病患者临床疗效的研究，报告有关人口统计学、临床症状、治疗和临床过程的信息。已开展GMA治疗的皮肤病包括泛发性脓疱型银屑病、坏疽性脓皮病、掌跖脓疱型银屑病、白塞病、Sweet综合征、成人斯蒂尔病、疱疹样脓疱病、反应性关节炎、痤疮和化脓性汗腺炎综合征、皮肤过敏性血管炎和系统性红斑狼疮。在大多数患者中，GMA在传统治疗方案失败后开始，并且在大多数病例中是有帮助的。根据总结的信息，GMA可被认为是几种皮肤病患者有效的非药物治疗选择，而这些皮肤病用其他药物制剂难以治疗。
