Welleschik B, Rasinger G A, Brunner E
HNO. 1987 Mar;35(3):119-27.
The theory that sudden hearing loss is caused by some form of vascular catastrophe has not been confirmed by pathological evidence, but it agrees with a number of clinical observations. But there are several pieces of experimental and clinical evidence that cast serious doubt upon a vascular hypothesis, especially the considerable variability in site and degree of cochlear and vestibular impairment. A review of the vascular anatomy of the inner ear makes it clear that many clinically observed audiometric patterns and associated partial vestibular deficits in idiopathic sudden hearing loss cannot be explained by assigning a site of presumed vascular occlusion. We investigated 166 pure tone audiograms of patients with idiopathic sudden hearing loss by using the statistical method of cluster analysis, which allow an explanation based on the vascular anatomy. Three types of audiograms could be found which differed not in shape but in the degree of hearing loss. None of them can be explained by the vascular anatomy. The three groups of audiograms with different degrees of hearing loss allowed investigations of the influence of age, sex, vestibular disturbance and vascular disease. Men are more often affected, the degree of the hearing loss is not dependent on age, vestibular disturbance, vascular disease, diabetes or smoking. The prognosis for sudden hearing loss is independent of all the investigated parameters. Our findings support the conclusion that a vascular hypothesis cannot adequately explain the clinical findings in idiopathic sudden hearing loss.
突发性听力损失是由某种形式的血管病变引起的这一理论尚未得到病理学证据的证实,但它与一些临床观察结果相符。然而,有若干实验和临床证据对血管假说提出了严重质疑,尤其是耳蜗和前庭损伤的部位及程度存在相当大的变异性。对内耳血管解剖结构的回顾表明,特发性突发性听力损失中许多临床观察到的听力图模式及相关的部分前庭功能缺损,无法通过指定假定的血管阻塞部位来解释。我们采用聚类分析的统计方法,对166例特发性突发性听力损失患者的纯音听力图进行了研究,聚类分析能够基于血管解剖结构做出解释。结果发现了三种类型的听力图,它们的差异不在于形状,而在于听力损失的程度。其中没有一种能用血管解剖结构来解释。这三组不同程度听力损失的听力图使得对年龄、性别、前庭功能障碍和血管疾病的影响进行研究成为可能。男性更易患病,听力损失程度与年龄、前庭功能障碍、血管疾病、糖尿病或吸烟无关。突发性听力损失的预后与所有研究参数均无关。我们的研究结果支持这样的结论:血管假说无法充分解释特发性突发性听力损失的临床发现。