De Palo G, Lattuada A, Kenda R, Musumeci R, Zanini M, Pilotti S, Bellani F F, Di Re F, Banfi A
Int J Radiat Oncol Biol Phys. 1987 Jun;13(6):853-60. doi: 10.1016/0360-3016(87)90099-x.
The experience of the Istituto Nazionale Tumori of Milan on dysgerminoma is presented. Between 1970 and December of 1982, 25 patients were treated with a unique protocol which considered surgery and radiotherapy with different schedules according to the extension of the disease. With this treatment protocol all 13 patients at Stage I were alive and free of disease with a median follow-up of 77 months. Of 12 patients at Stage III (10 retroperitoneal and 2 retroperitoneal and peritoneal) 4 relapsed. The 5-year relapse-free survival of Stage III patients was 61.4% and the overall survival 89.5%. Amenorrhea due to radiation dose absorbed by the contralateral shielded ovary was found in 7.7%. The excellent results in Stage I patients were balanced by the unsatisfactory results in Stage III patients. A more aggressive treatment and the knowledge of other prognostic factors seem necessary.
本文介绍了米兰国立肿瘤研究所治疗无性细胞瘤的经验。1970年至1982年12月期间，25例患者采用了独特的治疗方案，该方案根据疾病的分期采用不同的手术和放疗时间表。采用此治疗方案，所有13例I期患者均存活且无疾病复发，中位随访时间为77个月。12例III期患者（10例腹膜后、2例腹膜后及腹腔）中有4例复发。III期患者的5年无复发生存率为61.4%，总生存率为89.5%。7.7%的患者因对侧屏蔽卵巢吸收的辐射剂量导致闭经。I期患者的良好结果与III期患者的不理想结果形成对比。似乎需要更积极的治疗以及了解其他预后因素。
