基因和 基因多态性与慢性丙型肝炎患者肝纤维化严重程度无关。
Lack of Association of Polymorphisms in and Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
机构信息
Postgraduate Program in Health Sciences, University of Pernambuco (UPE), Recife, Brazil.
College of Medicine, Federal University of the São Francisco Valley (UNIVASF), Petrolina, Brazil.
出版信息
Viral Immunol. 2022 Sep;35(7):509-513. doi: 10.1089/vim.2022.0034. Epub 2022 Jul 15.
The IL-22 pathway has been shown to play an important role in the pathogenesis of liver fibrosis. However, little is known about the role of single-nucleotide polymorphisms (SNPs) in IL-22-related genes in relation to the severity of liver fibrosis. This study aimed to investigate the association of polymorphisms in and genes with the severity of liver fibrosis in patients with chronic hepatitis C. A total of 326 patients (165 with mild fibrosis and 161 with severe fibrosis) were included. Four SNPs in (rs1179251, rs2227473, rs1012356, and rs2227485) and two in (rs4648936 and rs3795299) were evaluated by real-time PCR. No significant association was observed between the polymorphisms studied and the severity of liver fibrosis. The SNPs rs1179251, rs2227473, rs1012356, and rs2227485 in and rs4648936 and rs3795299 in may not be involved in the pathogenesis of liver fibrosis in patients with chronic hepatitis C.
IL-22 通路在肝纤维化的发病机制中起着重要作用。然而，关于与肝纤维化严重程度相关的 IL-22 相关基因中单核苷酸多态性（SNPs）的作用知之甚少。本研究旨在探讨慢性丙型肝炎患者中 和 基因多态性与肝纤维化严重程度的关系。共纳入 326 例患者（165 例轻度纤维化，161 例重度纤维化）。通过实时 PCR 评估了 中的 4 个 SNP（rs1179251、rs2227473、rs1012356 和 rs2227485）和 中的 2 个 SNP（rs4648936 和 rs3795299）。研究的多态性与肝纤维化的严重程度之间没有观察到显著的相关性。 中的 rs1179251、rs2227473、rs1012356 和 rs2227485 以及 中的 rs4648936 和 rs3795299 可能不参与慢性丙型肝炎患者肝纤维化的发病机制。
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