Galwey Nicholas W
Research Statistics Group, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, UK.
Biom J. 2023 Jan;65(1):e2100309. doi: 10.1002/bimj.202100309. Epub 2022 Jul 15.
False discovery rates are routinely controlled by application of the Benjamini-Hochberg step-up procedure to a set of p-values. A method is demonstrated for representing the values so obtained (the BH-FDRs) on a quantile-quantile (Q-Q) plot of the p-values transformed to the negative-logarithmic scale. Recognition of this connection between the BH-FDR and the Q-Q plot facilitates both understanding of the meaning of the BH-FDR and interpretation of the BH-FDR in a particular data set.
通过将Benjamini-Hochberg逐步程序应用于一组p值,可常规控制错误发现率。本文展示了一种方法,用于在转换为负对数尺度的p值的分位数-分位数(Q-Q)图上表示由此获得的值(BH错误发现率)。认识到BH错误发现率与Q-Q图之间的这种联系,有助于理解BH错误发现率的含义,并有助于在特定数据集中解释BH错误发现率。