Department of Nutrition, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Epilepsy Behav. 2022 Sep;134:108820. doi: 10.1016/j.yebeh.2022.108820. Epub 2022 Jul 13.
We compared the efficacy and safety of ketogenic diet (KD) therapy as a treatment for Chinese adults versus children with drug-resistant epilepsy.
The classic KD was initiated in 19 adults and 29 children with drug-resistant epilepsy. The KD ratio and the dosage of antiseizure medication (ASM) were delicately modulated by the ketogenic team.
At 12 months after diet initiation, 11 adults (8 on a KD ratio of 3:1 and 3 on a ratio of 2:1) and 20 children (9 on a ketogenic diet ratio of 3:1 and 11 on a ratio of 2:1) remained on the diet. The retention rate for adult KD therapy recipients was 79.0% at 6 months and 57.9% at 12 months after diet initiation, which was not significantly different from the retention rate for children (82.8% at 6 months and 68.9% at 12 months; P > 0.05). The efficacy rate of KD therapy (seizure freedom or ≥50% reduction in seizure frequency) did not significantly differ between adults (63.2%) and children (75.8%, P = 0.517). Alleviation of seizure severity was observed in 68.4% of adults and 63.6% of children who were not seizure free on KD therapy. Antiseizure medication was reduced in 34 out of all 48 individuals at the final follow-up.
Our study demonstrated that KD therapy is a safe and effective treatment for Chinese adults as well as children with drug-resistant epilepsy.
我们比较了生酮饮食（KD）疗法治疗中国成年和儿童耐药性癫痫的疗效和安全性。
经典 KD 在 19 名成年和 29 名耐药性癫痫儿童中启动。KD 团队精细调节 KD 比例和抗癫痫药物（ASM）剂量。
在开始饮食后 12 个月，11 名成年人（8 名接受 3:1 KD 比例，3 名接受 2:1 比例）和 20 名儿童（9 名接受 3:1 KD 比例，11 名接受 2:1 比例）继续接受饮食治疗。成年 KD 治疗接受者的保留率在 6 个月时为 79.0%，在 12 个月时为 57.9%，与儿童的保留率（6 个月时为 82.8%，12 个月时为 68.9%；P>0.05）无显著差异。KD 治疗的疗效率（无发作或发作频率减少≥50%）在成年患者（63.2%）和儿童患者（75.8%，P=0.517）之间无显著差异。在 KD 治疗无发作的 68.4%成人和 63.6%儿童中观察到癫痫严重程度的缓解。在所有 48 名个体的最终随访中，有 34 名减少了抗癫痫药物。
我们的研究表明，KD 疗法是中国成年和儿童耐药性癫痫的一种安全有效的治疗方法。
