Yap Nicole Li Xian, Kor Qianyi, Teo Yao Neng, Teo Yao Hao, Syn Nicholas L, Evangelista Lauren Kay Mance, Tan Benjamin Yq, Lin Weiqin, Yeo Leonard Ll, Kong William Kf, Chong Yao Feng, Wong Raymond Cc, Poh Kian Keong, Yeo Tiong-Cheng, Sharma Vijay Kumar, Chai Ping, Chan Mark Y, Goh Fang Qin, Sia Ching-Hui
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 10, Singapore 119228.
Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, Singapore 119228.
Hellenic J Cardiol. 2022 Sep-Oct;67:48-58. doi: 10.1016/j.hjc.2022.07.005. Epub 2022 Jul 12.
The burden of cognitive impairment in heart failure (HF) patients is significant and leads to longer hospital stay, higher readmission rates, and increased mortality. This review seeks to synthesize the available studies to determine the prevalence and incidence of cognitive impairment and dementia in HF patients.
PubMed, Embase, PsychoINFO, and Cochrane databases were systematically searched from their inception through to May 3, 2021. Study and population characteristics, total patients with HF, prevalence of cognitive impairment and dementia in HF patients, and cognitive assessment tool were abstracted by two reviewers.
In HF patients, the overall prevalence for cognitive impairment and dementia was 41.42% (CI) and 19.79% (dementia), respectively. We performed a meta-regression analysis, which demonstrated that the risk of cognitive impairment and dementia increased with age.
Further research should investigate whether HF accelerates the rate of cognitive decline and the progression of dementia.
心力衰竭（HF）患者认知障碍的负担很重，会导致住院时间延长、再入院率升高和死亡率增加。本综述旨在综合现有研究，以确定HF患者认知障碍和痴呆的患病率及发病率。
对PubMed、Embase、PsychINFO和Cochrane数据库从创建至2021年5月3日进行系统检索。两名评审员提取了研究和人群特征、HF患者总数、HF患者认知障碍和痴呆的患病率以及认知评估工具。
在HF患者中，认知障碍和痴呆的总体患病率分别为41.42%（CI）和19.79%（痴呆）。我们进行了一项元回归分析，结果表明认知障碍和痴呆的风险随年龄增加而升高。
进一步的研究应调查HF是否会加速认知衰退的速度和痴呆的进展。
