自噬体成分在自溶酶体上的循环。
Autophagosomal components recycling on autolysosomes.
机构信息
School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cell Architecture Research Center, Huazhong University of Science and Technology, Wuhan, China.
School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Cell Architecture Research Center, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Trends Cell Biol. 2022 Nov;32(11):897-899. doi: 10.1016/j.tcb.2022.06.012. Epub 2022 Jul 12.
Autophagy is a multistage, intracellular process. Here, we highlight a recently identified autophagosomal components recycling (ACR) stage and the recycler complex (SNX4-SNX5-SNX17), which mediates recycling of autophagosomal outer membrane proteins on the autolysosome surface immediately following autophagosome-lysosome fusion. This discovery opens numerous research directions into the postfusion fate of autophagosomes.
自噬是一个多阶段的细胞内过程。在这里，我们重点介绍一个最近发现的自噬体成分再循环（ACR）阶段和再循环复合物（SNX4-SNX5-SNX17），它介导了自噬体-溶酶体融合后立即在自溶酶体表面上的自噬体外膜蛋白的再循环。这一发现为自噬体融合后的命运开辟了许多研究方向。
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